Seroatlas · Human Serome Atlas

LRP11

Low-density lipoprotein receptor-related protein 11

Also known as: bA350J20.3, LRP11_HUMAN, MANSC3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VZ4
Gene: LRP11
Ensembl: ENSG00000120256
Chromosome: 6
Canonical length: 500 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Enables phosphoprotein binding activity. Predicted to be involved in several processes, including response to cold; response to heat; and response to water deprivation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q86VZ4|LRP11
     1  MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE
    61  EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA
   121  PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG
   181  YSSYSLSRAP DGAALATARA SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI
   241  VQYEWALLQG DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA
   301  YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD RKMVTHTAAS
   361  PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR NHSAFWGPES QIIPVMPDSS
   421  SSGKNRKEES YIFESKGDGG GGEHPAPETG AVLPLALGLA ITALLLLMVA CRLRLVKQKL
   481  KKARPITSEE SDYLINGMYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 40 nTPM
cerebral cortex: 27 nTPM
prostate: 24 nTPM
basal ganglia: 23 nTPM
esophagus: 23 nTPM
thyroid gland: 22 nTPM

Single-cell type

podocytes: 85 nCPM
ependymal cells: 71 nCPM
late spermatids: 69 nCPM
renal collecting duct intercalated cells: 50 nCPM
papillary tip epithelial cells: 49 nCPM
brain excitatory neurons: 35 nCPM

Immune cell

memory B-cell: 0.3 nTPM
myeloid DC: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

cerebral cortex: 52 nTPM
hypothalamus: 49 nTPM
midbrain: 49 nTPM
basal ganglia: 48 nTPM
pons: 47 nTPM
white matter: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphoprotein binding

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRP11 as an antibody target. Whether an autoantibody or antibody against LRP11 could matter depends on whether native LRP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRP11 is annotated at the cell surface, where native LRP11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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