Seroatlas · Human Serome Atlas

LRP10

Low-density lipoprotein receptor-related protein 10

Also known as: DKFZP564C1940, LRP10_HUMAN, LRP9, MGC8675, MST087, MSTP087

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4F1
Gene: LRP10
Ensembl: ENSG00000197324
Chromosome: 14
Canonical length: 713 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

713 residues, UniProt reviewed canonical sequence.

>Q7Z4F1|LRP10
     1  MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS RTSPANCTWL
    61  ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA PPSPLQLPGG NVTITYSYAG
   121  ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH RCVSAVQRCD GVDACGDGSD EAGCSSDPFP
   181  GLTPRPVPSL PCNVTLEDFY GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD
   241  LGFGDAVHVY DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA
   301  TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE EDCPGCPPGH
   361  FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ PGNFRCRDEK CVYETWVCDG
   421  QPDCADGSDE WDCSYVLPRK VITAAVIGSL VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL
   481  SRMEAEIVQQ QAPPSYGQLI AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG
   541  GPGARRRQRG RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR
   601  EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL LSGVVQALRG
   661  RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG VWVAEAEDEP LLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 167 nTPM

Expression across tissuesHPA

Tissue

esophagus: 167 nTPM
blood vessel: 166 nTPM
colon: 104 nTPM
gallbladder: 102 nTPM
urinary bladder: 101 nTPM
vagina: 96 nTPM

Single-cell type

esophageal apical cells: 1,224 nCPM
neutrophils: 677 nCPM
esophageal suprabasal cells: 304 nCPM
enterocytes: 254 nCPM
colonocytes: 250 nCPM
syncytiotrophoblasts: 168 nCPM

Immune cell

neutrophil: 59 nTPM
eosinophil: 35 nTPM
basophil: 15 nTPM
T-reg: 12 nTPM
memory CD4 T-cell: 12 nTPM
memory CD8 T-cell: 11 nTPM

Brain region

medulla oblongata: 105 nTPM
choroid plexus: 103 nTPM
white matter: 71 nTPM
spinal cord: 69 nTPM
thalamus: 67 nTPM
basal ganglia: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

low-density lipoprotein particle receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRP10 as an antibody target. Whether an autoantibody or antibody against LRP10 could matter depends on whether native LRP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRP10 is annotated at the cell surface, where native LRP10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...