Seroatlas · Human Serome Atlas

LRCOL1

Leucine-rich colipase-like protein 1

Also known as: LRCL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCL2
Gene: LRCOL1
Ensembl: ENSG00000204583
Chromosome: 12
Canonical length: 159 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable enzyme activator activity. Predicted to be involved in digestion and lipid catabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>A6NCL2|LRCOL1
     1  MAGPGWTLLL LLLLLLLLGS MAGYGPQKKL NLSHKGIGEP CRRHEECQSN CCTINSLAPH
    61  TLCTPKTIFL QCLPWRKPNG YRCSHDSECQ SSCCVRNNSP QELCTPQSVF LQCVPWRKPN
   121  GDFCSSHQEC HSQCCIQLRE YSPFRCIPRT GILAQCLPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRCOL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

epididymis: 47 nTPM
lung: 0.9 nTPM
liver: 0.5 nTPM
fallopian tube: 0.4 nTPM
kidney: 0.4 nTPM
placenta: 0.3 nTPM

Single-cell type

epididymal principal cells: 785 nCPM
epididymal efferent duct absorptive cells: 158 nCPM
epididymal efferent duct ciliated cells: 44 nCPM
hepatocytes: 35 nCPM
lymphatic endothelial cells: 24 nCPM
epididymal basal cells: 17 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
thalamus: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

OntologyGO

Biological processes

Molecular functions

enzyme activator activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Colipase
Colipase-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRCOL1 as an antibody target. Whether an autoantibody or antibody against LRCOL1 could matter depends on whether native LRCOL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRCOL1 is annotated as secreted, so native LRCOL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LRCOL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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