Seroatlas · Human Serome Atlas

LRATD1

Protein LRATD1

Also known as: FAM84A, FLJ35392, LRAT1_HUMAN, NSE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KN4
Gene: LRATD1
Ensembl: ENSG00000162981
Chromosome: 2
Canonical length: 292 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in cell morphogenesis and cell motility. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q96KN4|LRATD1
     1  MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP DKFGVKAPPG
    61  CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS GGPQGADLSV YAVTALPALC
   121  EPGDLLELLW LQPAPEPPAP APHWAVYVGG GQIIHLHQGE IRQDSLYEAG AANVGRVVNS
   181  WYRYRPLVAE LVVQNACGHL GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ
   241  QQYYLKVHLG ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRATD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

colon: 38 nTPM
rectum: 34 nTPM
epididymis: 30 nTPM
esophagus: 27 nTPM
duodenum: 25 nTPM
small intestine: 24 nTPM

Single-cell type

syncytiotrophoblasts: 222 nCPM
urothelial cells: 220 nCPM
enteric stem cells: 204 nCPM
cytotrophoblasts: 199 nCPM
epididymal principal cells: 188 nCPM
esophageal apical cells: 185 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 61 nTPM
cerebral cortex: 58 nTPM
basal ganglia: 42 nTPM
hippocampal formation: 34 nTPM
white matter: 31 nTPM
hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.89
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRATD1 as an antibody target. Whether an autoantibody or antibody against LRATD1 could matter depends on whether native LRATD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRATD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRATD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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