Seroatlas · Human Serome Atlas

LRAT

Lecithin retinol acyltransferase

Also known as: LCA14, LRAT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95237
Gene
LRAT
Ensembl
ENSG00000121207
Chromosome
4
Canonical length
230 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus,Plasma membrane,Basal body

OverviewNCBI Gene

The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>O95237|LRAT
     1  MKNPMLEVVS LLLEKLLLIS NFTLFSSGAA GEDKGRNSFY ETSSFHRGDV LEVPRTHLTH
    61  YGIYLGDNRV AHMMPDILLA LTDDMGRTQK VVSNKRLILG VIVKVASIRV DTVEDFAYGA
   121  NILVNHLDES LQKKALLNEE VARRAEKLLG FTPYSLLWNN CEHFVTYCRY GTPISPQSDK
   181  FCETVKIIIR DQRSVLASAV LGLASIVCTG LVSYTTLPAI FIPFFLWMAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
2 nTPM

Expression across tissuesHPA

Tissue

  • liver: 2 nTPM
  • spinal cord: 1.9 nTPM
  • hypothalamus: 1.7 nTPM
  • small intestine: 1.5 nTPM
  • thyroid gland: 1.4 nTPM
  • basal ganglia: 1.2 nTPM

Single-cell type

  • retinal pigment epithelial cells: 1,957 nCPM
  • choroid plexus epithelial cells: 152 nCPM
  • melanocytes: 85 nCPM
  • schwann cells: 81 nCPM
  • cholangiocytes: 57 nCPM
  • pituitary stem cells: 42 nCPM

Immune cell

  • total PBMC: 2.2 nTPM
  • classical monocyte: 1.9 nTPM
  • myeloid DC: 1.5 nTPM
  • neutrophil: 0.7 nTPM
  • basophil: 0.6 nTPM
  • intermediate monocyte: 0.6 nTPM

Brain region

  • choroid plexus: 2.3 nTPM
  • pons: 1.8 nTPM
  • hypothalamus: 1.7 nTPM
  • medulla oblongata: 1.6 nTPM
  • midbrain: 1.4 nTPM
  • white matter: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LRAT.

Disease | AllUniProt

Conditions LRAT is implicated in, by any mechanism.

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 283 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.32
gnomAD pLI
0.03
gnomAD missense Z
-0.02
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRAT as an antibody target. Whether an autoantibody or antibody against LRAT could matter depends on whether native LRAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRAT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRAT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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