LPO

Protein identityUniProt · HPA

UniProt accession

P22079

Gene

LPO

Ensembl

ENSG00000167419

Chromosome

17

Canonical length

712 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to digestive system

OverviewNCBI Gene

This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

712 residues, UniProt reviewed canonical sequence.

>P22079|LPO
     1  MRVLLHLPAL LASLILLQAA ASTTRAQTTR TSAISDTVSQ AKVQVNKAFL DSRTRLKTAM
    61  SSETPTSRQL SEYLKHAKGR TRTAIRNGQV WEESLKRLRQ KASLTNVTDP SLDLTSLSLE
   121  VGCGAPAPVV RCDPCSPYRT ITGDCNNRRK PALGAANRAL ARWLPAEYED GLSLPFGWTP
   181  GKTRNGFPLP LAREVSNKIV GYLNEEGVLD QNRSLLFMQW GQIVDHDLDF APDTELGSSE
   241  YSKAQCDEYC IQGDNCFPIM FPPNDPKAGT QGKCMPFFRA GFVCPTPPYK SLAREQINAL
   301  TSFLDASFVY SSEPSLASRL RNLSSPLGLM AVNQEVSDHG LPYLPYDSKK PSPCEFINTT
   361  ARVPCFLAGD SRASEHILLA TSHTLFLREH NRLARELKRL NPQWDGEKLY QEARKILGAF
   421  VQIITFRDYL PILLGDHMQK WIPPYQGYSE SVDPRISNVF TFAFRFGHLE VPSSMFRLDE
   481  NYQPWGPEPE LPLHTLFFNT WRMVKDGGID PLVRGLLAKK SKLMKQNKMM TGELRNKLFQ
   541  PTHRIHGFDL AAINTQRCRD HGQPGYNSWR AFCDLSQPQT LEELNTVLKS KMLAKKLLGL
   601  YGTPDNIDIW IGAIAEPLVE RGRVGPLLAC LLGKQFQQIR DGDRFWWENP GVFTNEQKDS
   661  LQKMSFSRLV CDNTRITKVP RDPFWANSYP YDFVDCSAID KLDLSPWASV KN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

967 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.15

gnomAD pLI

0

gnomAD missense Z

0.24

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• defense response to bacterium
• detection of chemical stimulus involved in sensory perception of bitter taste
• hydrogen peroxide catabolic process
• response to oxidative stress

Molecular functions

• heme binding
• lactoperoxidase activity
• metal ion binding
• thiocyanate peroxidase activity

Cellular components

• basolateral plasma membrane
• cytoplasm
• extracellular exosome
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Haem peroxidase superfamily
• Haem peroxidase, animal-type
• Haem peroxidase domain superfamily, animal type
• Animal haem peroxidase

KeywordsUniProt

• Antimicrobial
• Calcium
• Cytoplasm
• Disulfide bond
• Glycoprotein
• Heme
• Hydrogen peroxide
• Iron
• Metal-binding
• Nitration
• Oxidoreductase
• Peroxidase
• Phosphoprotein
• Secreted
• Signal