Seroatlas · Human Serome Atlas

LPIN3

Phosphatidate phosphatase LPIN3

Also known as: LIPN3L, LPIN3_HUMAN, SMP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQK8
Gene: LPIN3
Ensembl: ENSG00000132793
Chromosome: 20
Canonical length: 851 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

851 residues, UniProt reviewed canonical sequence.

>Q9BQK8|LPIN3
     1  MNYVGQLAET VFGTVKELYR GLNPATLSGG IDVLVVKQVD GSFRCSPFHV RFGKLGVLRS
    61  REKVVDIELN GEPVDLHMKL GDSGEAFFVQ ELESDDEHVP PGLCTSPIPW GGLSGFPSDS
   121  QLGTASEPEG LVMAGTASTG RRKRRRRRKP KQKEDAVATD SSPEELEAGA ESELSLPEKL
   181  RPEPPGVQLE EKSSLQPKDI YPYSDGEWPP QASLSAGELT SPKSDSELEV RTPEPSPLRA
   241  ESHMQWAWGR LPKVARAERP ESSVVLEGRA GATSPPRGGP STPSTSVAGG VDPLGLPIQQ
   301  TEAGADLQPD TEDPTLVGPP LHTPETEESK TQSSGDMGLP PASKSWSWAT LEVPVPTGQP
   361  ERVSRGKGSP KRSQHLGPSD IYLDDLPSLD SENAALYFPQ SDSGLGARRW SEPSSQKSLR
   421  DPNPEHEPEP TLDTVDTIAL SLCGGLADSR DISLEKFNQH SVSYQDLTKN PGLLDDPNLV
   481  VKINGKHYNW AVAAPMILSL QAFQKNLPKS TMDKLEREKM PRKGGRWWFS WRRRDFLAEE
   541  RSAQKEKTAA KEQQGEKTEV LSSDDDAPDS PVILEIPSLP PSTPPSTPTY KKSLRLSSDQ
   601  IRRLNLQEGA NDVVFSVTTQ YQGTCRCKAT IYLWKWDDKV VISDIDGTIT KSDALGHILP
   661  QLGKDWTHQG ITSLYHKIQL NGYKFLYCSA RAIGMADLTK GYLQWVSEGG CSLPKGPILL
   721  SPSSLFSALH REVIEKKPEV FKVACLSDIQ QLFLPHGQPF YAAFGNRPND VFAYRQVGLP
   781  ESRIFTVNPR GELIQELIKN HKSTYERLGE VVELLFPPVA RGPSTDLANP EYSNFCYWRE
   841  PLPAVDLDTL D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

duodenum: 39 nTPM
skin: 38 nTPM
small intestine: 31 nTPM
esophagus: 30 nTPM
kidney: 29 nTPM
liver: 29 nTPM

Single-cell type

late spermatids: 291 nCPM
enterocytes: 88 nCPM
proximal tubule cells: 87 nCPM
esophageal apical cells: 73 nCPM
hepatocytes: 54 nCPM
foveolar cells: 49 nCPM

Immune cell

NK-cell: 2.3 nTPM
basophil: 0.8 nTPM
neutrophil: 0.6 nTPM
non-classical monocyte: 0.3 nTPM
eosinophil: 0.2 nTPM
MAIT T-cell: 0.2 nTPM

Brain region

choroid plexus: 13 nTPM
cerebral cortex: 8.6 nTPM
thalamus: 7.9 nTPM
medulla oblongata: 7.8 nTPM
white matter: 7.6 nTPM
amygdala: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LPIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

YWHAE

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPIN3 as an antibody target. Whether an autoantibody or antibody against LPIN3 could matter depends on whether native LPIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPIN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LPIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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