Seroatlas · Human Serome Atlas

LPGAT1

Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

Also known as: FAM34A, FAM34A1, KIAA0205, LGAT1_HUMAN, LPLAT7, NET8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92604
Gene
LPGAT1
Ensembl
ENSG00000123684
Chromosome
1
Canonical length
370 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q92604|LPGAT1
     1  MAITLEEAPW LGWLLVKALM RFAFMVVNNL VAIPSYICYV IILQPLRVLD SKRFWYIEGI
    61  MYKWLLGMVA SWGWYAGYTV MEWGEDIKAV SKDEAVMLVN HQATGDVCTL MMCLQDKGLV
   121  VAQMMWLMDH IFKYTNFGIV SLVHGDFFIR QGRSYRDQQL LLLKKHLENN YRSRDRKWIV
   181  LFPEGGFLRK RRETSQAFAK KNNLPFLTNV TLPRSGATKI ILNALVAQQK NGSPAGGDAK
   241  ELDSKSKGLQ WIIDTTIAYP KAEPIDIQTW ILGYRKPTVT HVHYRIFPIK DVPLETDDLT
   301  TWLYQRFVEK EDLLSHFYET GAFPPSKGHK EAVSREMTLS NLWIFLIQSF AFLSGYMWYN
   361  IIQYFYHCLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPGAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • retina: 38 nTPM
  • liver: 34 nTPM
  • small intestine: 33 nTPM
  • thyroid gland: 24 nTPM
  • duodenum: 22 nTPM
  • testis: 21 nTPM

Single-cell type

  • neutrophils: 900 nCPM
  • neutrophil progenitors: 707 nCPM
  • oligodendrocytes: 663 nCPM
  • early spermatids: 640 nCPM
  • choroid plexus epithelial cells: 530 nCPM
  • retinal pigment epithelial cells: 405 nCPM

Immune cell

  • eosinophil: 16 nTPM
  • basophil: 12 nTPM
  • neutrophil: 12 nTPM
  • NK-cell: 5.3 nTPM
  • myeloid DC: 3.2 nTPM
  • classical monocyte: 2.7 nTPM

Brain region

  • white matter: 94 nTPM
  • basal ganglia: 76 nTPM
  • midbrain: 65 nTPM
  • choroid plexus: 61 nTPM
  • thalamus: 61 nTPM
  • cerebral cortex: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LPGAT1.

Disease | ImmuneIEDB

Conditions an epitope on LPGAT1 was assayed in.

  • bladder carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.39
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPGAT1 as an antibody target. Whether an autoantibody or antibody against LPGAT1 could matter depends on whether native LPGAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPGAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LPGAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPGAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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