Seroatlas · Human Serome Atlas

LPCAT4

Lysophospholipid acyltransferase LPCAT4

Also known as: AGPAT7, AYTL3, FLJ10257, LPAAT-eta, LPCT4_HUMAN, LPEAT2, LPLAT10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q643R3
Gene
LPCAT4
Ensembl
ENSG00000176454
Chromosome
15
Canonical length
524 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q643R3|LPCAT4
     1  MSQGSPGDWA PLDPTPGPPA SPNPFVHELH LSRLQRVKFC LLGALLAPIR VLLAFIVLFL
    61  LWPFAWLQVA GLSEEQLQEP ITGWRKTVCH NGVLGLSRLL FFLLGFLRIR VRGQRASRLQ
   121  APVLVAAPHS TFFDPIVLLP CDLPKVVSRA ENLSVPVIGA LLRFNQAILV SRHDPASRRR
   181  VVEEVRRRAT SGGKWPQVLF FPEGTCSNKK ALLKFKPGAF IAGVPVQPVL IRYPNSLDTT
   241  SWAWRGPGVL KVLWLTASQP CSIVDVEFLP VYHPSPEESR DPTLYANNVQ RVMAQALGIP
   301  ATECEFVGSL PVIVVGRLKV ALEPQLWELG KVLRKAGLSA GYVDAGAEPG RSRMISQEEF
   361  ARQLQLSDPQ TVAGAFGYFQ QDTKGLVDFR DVALALAALD GGRSLEELTR LAFELFAEEQ
   421  AEGPNRLLYK DGFSTILHLL LGSPHPAATA LHAELCQAGS SQGLSLCQFQ NFSLHDPLYG
   481  KLFSTYLRPP HTSRGTSQTP NASSPGNPTA LANGTVQAPK QKGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPCAT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 60 nTPM
  • cerebral cortex: 49 nTPM
  • basal ganglia: 46 nTPM
  • colon: 40 nTPM
  • stomach: 34 nTPM
  • esophagus: 33 nTPM

Single-cell type

  • foveolar cells: 241 nCPM
  • esophageal apical cells: 207 nCPM
  • urothelial cells: 114 nCPM
  • prostatic hillock cells: 113 nCPM
  • colonocytes: 90 nCPM
  • retinal ganglion cells: 77 nCPM

Immune cell

  • MAIT T-cell: 5.7 nTPM
  • T-reg: 4.7 nTPM
  • plasmacytoid DC: 3.9 nTPM
  • memory CD8 T-cell: 3.5 nTPM
  • eosinophil: 3.1 nTPM
  • neutrophil: 3 nTPM

Brain region

  • cerebral cortex: 84 nTPM
  • pons: 58 nTPM
  • medulla oblongata: 49 nTPM
  • hypothalamus: 48 nTPM
  • white matter: 46 nTPM
  • thalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.48
gnomAD missense Z
1.55
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPCAT4 as an antibody target. Whether an autoantibody or antibody against LPCAT4 could matter depends on whether native LPCAT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPCAT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LPCAT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPCAT4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...