Seroatlas · Human Serome Atlas

LPCAT2

Lysophosphatidylcholine acyltransferase 2

Also known as: AGPAT11, AYTL1, FLJ20481, LPLAT9, LysoPAFAT, PCAT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L5N7
Gene
LPCAT2
Ensembl
ENSG00000087253
Chromosome
16
Canonical length
544 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Lipid droplets

OverviewNCBI Gene

This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q7L5N7|LPCAT2
     1  MSRCAQAAEV AATVPGAGVG NVGLRPPMVP RQASFFPPPV PNPFVQQTQI GSARRVQIVL
    61  LGIILLPIRV LLVALILLLA WPFAAISTVC CPEKLTHPIT GWRRKITQTA LKFLGRAMFF
   121  SMGFIVAVKG KIASPLEAPV FVAAPHSTFF DGIACVVAGL PSMVSRNENA QVPLIGRLLR
   181  AVQPVLVSRV DPDSRKNTIN EIIKRTTSGG EWPQILVFPE GTCTNRSCLI TFKPGAFIPG
   241  VPVQPVLLRY PNKLDTVTWT WQGYTFIQLC MLTFCQLFTK VEVEFMPVQV PNDEEKNDPV
   301  LFANKVRNLM AEALGIPVTD HTYEDCRLMI SAGQLTLPME AGLVEFTKIS RKLKLDWDGV
   361  RKHLDEYASI ASSSKGGRIG IEEFAKYLKL PVSDVLRQLF ALFDRNHDGS IDFREYVIGL
   421  AVLCNPSNTE EIIQVAFKLF DVDEDGYITE EEFSTILQAS LGVPDLDVSG LFKEIAQGDS
   481  ISYEEFKSFA LKHPEYAKIF TTYLDLQTCH VFSLPKEVQT TPSTASNKVS PEKHEESTSD
   541  KKDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPCAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 83 nTPM
  • thyroid gland: 81 nTPM
  • epididymis: 35 nTPM
  • seminal vesicle: 27 nTPM
  • spinal cord: 17 nTPM
  • endometrium: 17 nTPM

Single-cell type

  • microglia: 731 nCPM
  • neutrophil progenitors: 539 nCPM
  • neutrophils: 499 nCPM
  • mast cells: 249 nCPM
  • hematopoietic stem cells: 194 nCPM
  • kupffer cells: 180 nCPM

Immune cell

  • eosinophil: 200 nTPM
  • basophil: 152 nTPM
  • neutrophil: 47 nTPM
  • non-classical monocyte: 39 nTPM
  • intermediate monocyte: 27 nTPM
  • myeloid DC: 21 nTPM

Brain region

  • white matter: 48 nTPM
  • medulla oblongata: 34 nTPM
  • spinal cord: 27 nTPM
  • pons: 27 nTPM
  • choroid plexus: 23 nTPM
  • cerebellum: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LPCAT2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 75 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
2.01
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPCAT2 as an antibody target. Whether an autoantibody or antibody against LPCAT2 could matter depends on whether native LPCAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPCAT2 is annotated at the cell surface, where native LPCAT2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPCAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPCAT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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