Seroatlas · Human Serome Atlas

LPCAT1

Lysophosphatidylcholine acyltransferase 1

Also known as: AGPAT10, AGPAT9, AYTL2, FLJ12443, LPLAT8, PCAT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NF37
Gene
LPCAT1
Ensembl
ENSG00000153395
Chromosome
5
Canonical length
534 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Lipid droplets

OverviewNCBI Gene

This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q8NF37|LPCAT1
     1  MRLRGCGPRA APASSAGASD ARLLAPPGRN PFVHELRLSA LQKAQVALMT LTLFPVRLLV
    61  AAAMMLLAWP LALVASLGSA EKEPEQPPAL WRKVVDFLLK AIMRTMWFAG GFHRVAVKGR
   121  QALPTEAAIL TLAPHSSYFD AIPVTMTMSS IVMKAESRDI PIWGTLIQYI RPVFVSRSDQ
   181  DSRRKTVEEI KRRAQSNGKW PQIMIFPEGT CTNRTCLITF KPGAFIPGAP VQPVVLRYPN
   241  KLDTITWTWQ GPGALEILWL TLCQFHNQVE IEFLPVYSPS EEEKRNPALY ASNVRRVMAE
   301  ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPEKLEK DLDRYSERAR
   361  MKGGEKIGIA EFAASLEVPV SDLLEDMFSL FDESGSGEVD LRECVVALSV VCRPARTLDT
   421  IQLAFKMYGA QEDGSVGEGD LSCILKTALG VAELTVTDLF RAIDQEEKGK ITFADFHRFA
   481  EMYPAFAEEY LYPDQTHFES CAETSPAPIP NGFCADFSPE NSDAGRKPVR KKLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPCAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • lung: 54 nTPM
  • spleen: 36 nTPM
  • cerebellum: 15 nTPM
  • blood vessel: 14 nTPM
  • endometrium: 11 nTPM
  • urinary bladder: 11 nTPM

Single-cell type

  • neutrophils: 93 nCPM
  • alveolar cells type 2: 68 nCPM
  • alveolar cells type 1: 66 nCPM
  • rod photoreceptor cells: 62 nCPM
  • nk-cells: 59 nCPM
  • transitional alveolar cells: 40 nCPM

Immune cell

  • gdT-cell: 1.1 nTPM
  • MAIT T-cell: 1.1 nTPM
  • neutrophil: 0.8 nTPM
  • intermediate monocyte: 0.5 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • NK-cell: 0.5 nTPM

Brain region

  • cerebral cortex: 50 nTPM
  • hypothalamus: 39 nTPM
  • pons: 35 nTPM
  • hippocampal formation: 34 nTPM
  • midbrain: 32 nTPM
  • thalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.14
gnomAD missense Z
1.61
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPCAT1 as an antibody target. Whether an autoantibody or antibody against LPCAT1 could matter depends on whether native LPCAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPCAT1 is annotated at the cell surface, where native LPCAT1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPCAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LPCAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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