Seroatlas · Human Serome Atlas

LPAR6

Lysophosphatidic acid receptor 6

Also known as: LPAR6_HUMAN, P2RY5, P2Y5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P43657
Gene: LPAR6
Ensembl: ENSG00000139679
Chromosome: 13
Canonical length: 344 aa
Protein class: Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>P43657|LPAR6
     1  MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN ETTTYMINLA
    61  MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY
   121  PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP AVFVQSTHSQ GNNASEACFE NFPEATWKTY
   181  LSRIVIFIEI VGFFIPLILN VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF
   241  CFVPYNINLI LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
   301  SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPAR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

esophagus: 86 nTPM
vagina: 82 nTPM
placenta: 73 nTPM
prostate: 65 nTPM
salivary gland: 63 nTPM
cervix: 59 nTPM

Single-cell type

microglia: 893 nCPM
early spermatids: 443 nCPM
late spermatids: 413 nCPM
epicardial cells: 343 nCPM
esophageal apical cells: 319 nCPM
cdc: 313 nCPM

Immune cell

intermediate monocyte: 112 nTPM
non-classical monocyte: 104 nTPM
T-reg: 84 nTPM
classical monocyte: 72 nTPM
memory CD4 T-cell: 70 nTPM
total PBMC: 58 nTPM

Brain region

white matter: 28 nTPM
medulla oblongata: 24 nTPM
spinal cord: 23 nTPM
choroid plexus: 22 nTPM
pons: 19 nTPM
thalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LPAR6.

Disease | AllUniProt

Conditions LPAR6 is implicated in, by any mechanism.

Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) MIM:278150
Hypotrichosis 8 (HYPT8) MIM:278150

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 96 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypotrichosis 8
Wooly hair, autosomal recessive 1, with or without hypotrichosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lysophosphatidic acid receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPAR6 as an antibody target. Whether an autoantibody or antibody against LPAR6 could matter depends on whether native LPAR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPAR6 is annotated at the cell surface, where native LPAR6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPAR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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