Seroatlas · Human Serome Atlas

LPAR5

Lysophosphatidic acid receptor 5

Also known as: GPR92, GPR93, KPG_010, LPA5, LPAR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1C0
Gene: LPAR5
Ensembl: ENSG00000184574
Chromosome: 12
Canonical length: 372 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q9H1C0|LPAR5
     1  MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA LRVHSVVSVY
    61  MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI FQMNMYGSCI FLMLINVDRY
   121  AAIVHPLRLR HLRRPRVARL LCLGVWALIL VFAVPAARVH RPSRCRYRDL EVRLCFESFS
   181  DELWKGRLLP LVLLAEALGF LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL
   241  VIFLLCFVPY NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS
   301  AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG LLRPSDSHSL
   361  SSFTQCPQDS AL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPAR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

esophagus: 21 nTPM
tonsil: 12 nTPM
vagina: 9.7 nTPM
duodenum: 9.2 nTPM
spleen: 9 nTPM
small intestine: 8.6 nTPM

Single-cell type

microglia: 120 nCPM
esophageal apical cells: 90 nCPM
hofbauer cells: 82 nCPM
esophageal suprabasal cells: 64 nCPM
platelets: 55 nCPM
kupffer cells: 46 nCPM

Immune cell

memory B-cell: 84 nTPM
naive B-cell: 83 nTPM
gdT-cell: 67 nTPM
MAIT T-cell: 51 nTPM
memory CD8 T-cell: 40 nTPM
naive CD8 T-cell: 25 nTPM

Brain region

white matter: 29 nTPM
thalamus: 24 nTPM
spinal cord: 20 nTPM
medulla oblongata: 20 nTPM
pons: 17 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.05
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPAR5 as an antibody target. Whether an autoantibody or antibody against LPAR5 could matter depends on whether native LPAR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPAR5 is annotated at the cell surface, where native LPAR5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPAR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...