LPAR4
Lysophosphatidic acid receptor 4
Also known as: GPR23, LPA4, LPAR4_HUMAN, P2RY9, P2Y5-LIKE, P2Y9
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99677
- Gene
- LPAR4
- Ensembl
- ENSG00000147145
- Chromosome
- X
- Canonical length
- 370 aa
- Protein class
- G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Nuclear bodies,Vesicles,Plasma membrane
OverviewNCBI Gene
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
Canonical amino-acid sequenceUniProt
370 residues, UniProt reviewed canonical sequence.
>Q99677|LPAR4
1 MGDRRFIDFQ FQDSNSSLRP RLGNATANNT CIVDDSFKYN LNGAVYSVVF ILGLITNSVS
61 LFVFCFRMKM RSETAIFITN LAVSDLLFVC TLPFKIFYNF NRHWPFGDTL CKISGTAFLT
121 NIYGSMLFLT CISVDRFLAI VYPFRSRTIR TRRNSAIVCA GVWILVLSGG ISASLFSTTN
181 VNNATTTCFE GFSKRVWKTY LSKITIFIEV VGFIIPLILN VSCSSVVLRT LRKPATLSQI
241 GTNKKKVLKM ITVHMAVFVV CFVPYNSVLF LYALVRSQAI TNCFLERFAK IMYPITLCLA
301 TLNCCFDPFI YYFTLESFQK SFYINAHIRM ESLFKTETPL TTKPSLPAIQ EEVSDQTTNN
361 GGELMLESTFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LPAR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 3.1 nTPM
Expression across tissuesHPA
Tissue
- ovary: 3.1 nTPM
- hippocampal formation: 1.2 nTPM
- cerebral cortex: 1.1 nTPM
- skeletal muscle: 1 nTPM
- amygdala: 0.9 nTPM
- endometrium: 0.7 nTPM
Single-cell type
- leydig cells: 45 nCPM
- ependymal cells: 35 nCPM
- astrocytes: 20 nCPM
- bergmann glia: 19 nCPM
- oligodendrocyte progenitor cells: 9.9 nCPM
- thymocytes: 7.6 nCPM
Immune cell
- basophil: 7.8 nTPM
- neutrophil: 1.2 nTPM
- eosinophil: 1 nTPM
- non-classical monocyte: 1 nTPM
- NK-cell: 0.8 nTPM
- memory B-cell: 0.6 nTPM
Brain region
- white matter: 6 nTPM
- hippocampal formation: 4.6 nTPM
- spinal cord: 3.9 nTPM
- amygdala: 2.5 nTPM
- medulla oblongata: 2.5 nTPM
- cerebral cortex: 2.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.77
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.94
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LPAR4 as an antibody target. Whether an autoantibody or antibody against LPAR4 could matter depends on whether native LPAR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LPAR4 is annotated at the cell surface, where native LPAR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LPAR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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