Seroatlas · Human Serome Atlas

LPAR3

Lysophosphatidic acid receptor 3

Also known as: Edg-7, EDG7, HOFNH30, LP-A3, LPA3, LPAR3_HUMAN, RP4-678I3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBY5
Gene: LPAR3
Ensembl: ENSG00000171517
Chromosome: 1
Canonical length: 353 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane,Primary cilium

OverviewNCBI Gene

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q9UBY5|LPAR3
     1  MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVIKNRK
    61  FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD SSLTASLTNL
   121  LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA
   181  PIYSRSYLVF WTVSNLMAFL IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT
   241  VMTVLGAFVV CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM
   301  YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK STS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LPAR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 34 nTPM
prostate: 13 nTPM
cervix: 9.8 nTPM
pancreas: 9.8 nTPM
testis: 9.7 nTPM
heart muscle: 9.6 nTPM

Single-cell type

endometrial luminal cells: 125 nCPM
sertoli cells: 122 nCPM
fallopian tube ciliated cells: 106 nCPM
prostatic glandular cells: 84 nCPM
respiratory ciliated cells: 74 nCPM
ependymal cells: 60 nCPM

Immune cell

basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 17 nTPM
cerebral cortex: 7.7 nTPM
hippocampal formation: 7.2 nTPM
basal ganglia: 6 nTPM
white matter: 5.6 nTPM
midbrain: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.68
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
Lysophosphatidic acid receptor
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Lysophosphatidic acid receptor EDG-7

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LPAR3 as an antibody target. Whether an autoantibody or antibody against LPAR3 could matter depends on whether native LPAR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LPAR3 is annotated at the cell surface, where native LPAR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LPAR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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