Seroatlas · Human Serome Atlas

LORICRIN

Loricrin

Also known as: LOR, LORI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23490
Gene
LORICRIN
Ensembl
ENSG00000203782
Chromosome
1
Canonical length
312 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>P23490|LORICRIN
     1  MSYQKKQPTP QPPVDCVKTS GGGGGGGGSG GGGCGFFGGG GSGGGSSGSG CGYSGGGGYS
    61  GGGCGGGSSG GGGGGGIGGC GGGSGGSVKY SGGGGSSGGG SGCFSSGGGG SGCFSSGGGG
   121  SSGGGSGCFS SGGGGSSGGG SGCFSSGGGG FSGQAVQCQS YGGVSSGGSS GGGSGCFSSG
   181  GGGGSVCGYS GGGSGCGGGS SGGSGSGYVS SQQVTQTSCA PQPSYGGGSS GGGGSGGSGC
   241  FSSGGGGGSS GCGGGSSGIG SGCIISGGGS VCGGGSSGGG GGGSSVGGSG SGKGVPICHQ
   301  TQQKQAPTWP SK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LORICRIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.75
Highest tissue expression
1,773 nTPM

Expression across tissuesHPA

Tissue

  • skin: 1,773 nTPM
  • cervix: 45 nTPM
  • breast: 23 nTPM
  • vagina: 13 nTPM
  • skeletal muscle: 10 nTPM
  • salivary gland: 4.5 nTPM

Single-cell type

  • other brain neurons: 5.8 nCPM
  • oligodendrocyte progenitor cells: 5.1 nCPM
  • retinal amacrine cells: 4.8 nCPM
  • cdc: 4.7 nCPM
  • ovarian stromal cells: 4 nCPM
  • esophageal apical cells: 3.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 2 nTPM
  • medulla oblongata: 1.4 nTPM
  • pons: 1.2 nTPM
  • amygdala: 1.1 nTPM
  • basal ganglia: 1 nTPM
  • midbrain: 1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LORICRIN.

Disease | AllUniProt

Conditions LORICRIN is implicated in, by any mechanism.

  • Vohwinkel syndrome with ichthyosis (VSI) MIM:604117

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 142 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0.33
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Loricrin
  • Major keratinocyte cell envelope protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LORICRIN as an antibody target. Whether an autoantibody or antibody against LORICRIN could matter depends on whether native LORICRIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LORICRIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LORICRIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LORICRIN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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