Seroatlas · Human Serome Atlas

LNPK

Endoplasmic reticulum junction formation protein lunapark

Also known as: KIAA1715, LNP, LNP_HUMAN, LNP1, Ul

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0E8
Gene
LNPK
Ensembl
ENSG00000144320
Chromosome
2
Canonical length
428 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Endoplasmic reticulum,Connecting piece,Mid piece,Principal piece,End piece
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Located in endoplasmic reticulum tubular network membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q9C0E8|LNPK
     1  MGGLFSRWRT KPSTVEVLES IDKEIQALEE FREKNQRLQK LWVGRLILYS SVLYLFTCLI
    61  VYLWYLPDEF TARLAMTLPF FAFPLIIWSI RTVIIFFFSK RTERNNEALD DLKSQRKKIL
   121  EEVMEKETYK TAKLILERFD PDSKKAKECE PPSAGAAVTA RPGQEIRQRT AAQRNLSPTP
   181  ASPNQGPPPQ VPVSPGPPKD SSAPGGPPER TVTPALSSNV LPRHLGSPAT SVPGMGLHPP
   241  GPPLARPILP RERGALDRIV EYLVGDGPQN RYALICQQCF SHNGMALKEE FEYIAFRCAY
   301  CFFLNPARKT RPQAPRLPEF SFEKRQVVEG SSSVGPLPSG SVLSSDNQFN EESLEHDVLD
   361  DNTEQTDDKI PATEQTNQVI EKASDSEEPE EKQETENEEA SVIETNSTVP GADSIPDPEL
   421  SGESLTAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LNPK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 32 nTPM
  • bone marrow: 28 nTPM
  • tongue: 25 nTPM
  • testis: 23 nTPM
  • retina: 22 nTPM
  • cerebral cortex: 21 nTPM

Single-cell type

  • neutrophil progenitors: 340 nCPM
  • early spermatids: 305 nCPM
  • myonuclei: 221 nCPM
  • thymic myoid cells: 197 nCPM
  • late spermatids: 176 nCPM
  • cardiomyocytes: 173 nCPM

Immune cell

  • eosinophil: 7.9 nTPM
  • T-reg: 7.8 nTPM
  • naive CD8 T-cell: 6.7 nTPM
  • NK-cell: 6.6 nTPM
  • MAIT T-cell: 5.8 nTPM
  • memory CD8 T-cell: 5.4 nTPM

Brain region

  • white matter: 60 nTPM
  • pons: 53 nTPM
  • hypothalamus: 50 nTPM
  • medulla oblongata: 48 nTPM
  • spinal cord: 46 nTPM
  • cerebellum: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LNPK.

Disease | AllUniProt

Conditions LNPK is implicated in, by any mechanism.

  • Neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum (NEDEHCC) MIM:618090

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 63 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with epilepsy and hypoplasia of the corpus callosum

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Lunapark zinc ribbon domain
  • Lunapark family
  • ER junction formation factor lunapark, zinc ribbon finger

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LNPK as an antibody target. Whether an autoantibody or antibody against LNPK could matter depends on whether native LNPK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LNPK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LNPK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LNPK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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