LNP1
Leukemia NUP98 fusion partner 1
Also known as: LNP1_HUMAN, NP3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A1A4G5
- Gene
- LNP1
- Ensembl
- ENSG00000206535
- Chromosome
- 3
- Canonical length
- 178 aa
- Protein class
- Disease related genes, Predicted intracellular proteins
- Subcellular location
- Nuclear speckles,Vesicles,Cytosol
OverviewNCBI Gene
Enables identical protein binding activity. Involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Located in endoplasmic reticulum tubular network membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
178 residues, UniProt reviewed canonical sequence.
>A1A4G5|LNP1
1 MEHKDDDDDD VSFAKWMSSF WGHSWREEDQ RGLRERHRLQ ATSHRKTSLP CPLPVLPRIP
61 SSDCHPRRHS HEDQEFRCRS HVRDYRKYSE DGSFKEPLES KGRSHSKIEK FSESFERQLC
121 FRTKRSASLG PESRKERNER ECLRMEIKSR KKVEEERSSR KEEHGEAHMA PLFEKGPELocalizationUniProt · AlphaFold · HPA
Whether an antibody against LNP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- retina: 43 nTPM
- testis: 27 nTPM
- basal ganglia: 11 nTPM
- cerebral cortex: 9.4 nTPM
- blood vessel: 8.1 nTPM
- heart muscle: 7.9 nTPM
Single-cell type
- late primary spermatocytes: 243 nCPM
- retinal horizontal cells: 216 nCPM
- early spermatids: 137 nCPM
- cone photoreceptor cells: 89 nCPM
- rod photoreceptor cells: 63 nCPM
- retinal bipolar cells: 49 nCPM
Immune cell
- T-reg: 1.4 nTPM
- MAIT T-cell: 0.9 nTPM
- gdT-cell: 0.4 nTPM
- naive CD4 T-cell: 0.4 nTPM
- naive CD8 T-cell: 0.4 nTPM
- memory B-cell: 0.3 nTPM
Brain region
- pons: 10 nTPM
- hypothalamus: 9.3 nTPM
- basal ganglia: 8.9 nTPM
- cerebral cortex: 8.7 nTPM
- cerebellum: 7.7 nTPM
- white matter: 7.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.75
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.36
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Leukemia NUP98 fusion partner 1
- Leukemia NUP98 fusion partner 1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LNP1 as an antibody target. Whether an autoantibody or antibody against LNP1 could matter depends on whether native LNP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LNP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LNP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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