Seroatlas · Human Serome Atlas

LMTK3

Serine/threonine-protein kinase LMTK3

Also known as: KIAA1883, LMR3, LMTK3_HUMAN, PPP1R101, TYKLM3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96Q04
Gene: LMTK3
Ensembl: ENSG00000142235
Chromosome: 19
Canonical length: 1460 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

Predicted to enable protein kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in Golgi membrane; axon; and dendrite. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1460 residues, UniProt reviewed canonical sequence.

>Q96Q04|LMTK3
     1  MPAPGALILL AAVSASGCLA SPAHPDGFAL GRAPLAPPYA VVLISCSGLL AFIFLLLTCL
    61  CCKRGDVGFK EFENPEGEDC SGEYTPPAEE TSSSQSLPDV YILPLAEVSL PMPAPQPSHS
   121  DMTTPLGLSR QHLSYLQEIG SGWFGKVILG EIFSDYTPAQ VVVKELRASA GPLEQRKFIS
   181  EAQPYRSLQH PNVLQCLGLC VETLPFLLIM EFCQLGDLKR YLRAQRPPEG LSPELPPRDL
   241  RTLQRMGLEI ARGLAHLHSH NYVHSDLALR NCLLTSDLTV RIGDYGLAHS NYKEDYYLTP
   301  ERLWIPLRWA APELLGELHG TFMVVDQSRE SNIWSLGVTL WELFEFGAQP YRHLSDEEVL
   361  AFVVRQQHVK LARPRLKLPY ADYWYDILQS CWRPPAQRPS ASDLQLQLTY LLSERPPRPP
   421  PPPPPPRDGP FPWPWPPAHS APRPGTLSSP FPLLDGFPGA DPDDVLTVTE SSRGLNLECL
   481  WEKARRGAGR GGGAPAWQPA SAPPAPHANP SNPFYEALST PSVLPVISAR SPSVSSEYYI
   541  RLEEHGSPPE PLFPNDWDPL DPGVPAPQAP QAPSEVPQLV SETWASPLFP APRPFPAQSS
   601  ASGSFLLSGW DPEGRGAGET LAGDPAEVLG ERGTAPWVEE EEEEEEGSSP GEDSSSLGGG
   661  PSRRGPLPCP LCSREGACSC LPLERGDAVA GWGGHPALGC PHPPEDDSSL RAERGSLADL
   721  PMAPPASAPP EFLDPLMGAA APQYPGRGPP PAPPPPPPPP RAPADPAASP DPPSAVASPG
   781  SGLSSPGPKP GDSGYETETP FSPEGAFPGG GAAEEEGVPR PRAPPEPPDP GAPRPPPDPG
   841  PLPLPGPREK PTFVVQVSTE QLLMSLREDV TRNLLGEKGA TARETGPRKA GRGPGNREKV
   901  PGLNRDPTVL GNGKQAPSLS LPVNGVTVLE NGDQRAPGIE EKAAENGALG SPEREEKVLE
   961  NGELTPPRRE EKALENGELR SPEAGEKVLV NGGLTPPKSE DKVSENGGLR FPRNTERPPE
  1021  TGPWRAPGPW EKTPESWGPA PTIGEPAPET SLERAPAPSA VVSSRNGGET APGPLGPAPK
  1081  NGTLEPGTER RAPETGGAPR APGAGRLDLG SGGRAPVGTG TAPGGGPGSG VDAKAGWVDN
  1141  TRPQPPPPPL PPPPEAQPRR LEPAPPRARP EVAPEGEPGA PDSRAGGDTA LSGDGDPPKP
  1201  ERKGPEMPRL FLDLGPPQGN SEQIKARLSR LSLALPPLTL TPFPGPGPRR PPWEGADAGA
  1261  AGGEAGGAGA PGPAEEDGED EDEDEEEDEE AAAPGAAAGP RGPGRARAAP VPVVVSSADA
  1321  DAARPLRGLL KSPRGADEPE DSELERKRKM VSFHGDVTVY LFDQETPTNE LSVQAPPEGD
  1381  TDPSTPPAPP TPPHPATPGD GFPSNDSGFG GSFEWAEDFP LLPPPGPPLC FSRFSVSPAL
  1441  ETPGPPARAP DARPAGPVEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMTK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 59 nTPM
cerebral cortex: 55 nTPM
hippocampal formation: 47 nTPM
cerebellum: 38 nTPM
amygdala: 38 nTPM
hypothalamus: 32 nTPM

Single-cell type

rod photoreceptor cells: 222 nCPM
breast secretory cells: 85 nCPM
brain inhibitory neurons: 73 nCPM
brain excitatory neurons: 59 nCPM
other brain neurons: 59 nCPM
endometrial secretory cells: 55 nCPM

Immune cell

memory CD8 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
T-reg: 0.4 nTPM
gdT-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

cerebral cortex: 130 nTPM
hippocampal formation: 115 nTPM
basal ganglia: 106 nTPM
amygdala: 97 nTPM
white matter: 92 nTPM
hypothalamus: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 4.32
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMTK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ESR1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMTK3 as an antibody target. Whether an autoantibody or antibody against LMTK3 could matter depends on whether native LMTK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMTK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMTK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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