Seroatlas · Human Serome Atlas

LMNTD2

Lamin tail domain-containing protein 2

Also known as: C11orf35, LMTD2_HUMAN, MGC35138

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXW0
Gene
LMNTD2
Ensembl
ENSG00000185522
Chromosome
11
Canonical length
634 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytoplasmic bodies

OverviewNCBI Gene

Predicted to be a structural constituent of chromatin. Predicted to act upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in lamin filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>Q8IXW0|LMNTD2
     1  MRWLRPAGRR REQESVSGHL GPPAGAPAAP ETPTCLPDTT PHPAPVVCSA DPQLALESLD
    61  PRTLRLLWRQ RELEIQALRW AIQNGEDARL CHILEEVAGL PPKRSSHSQE KLLQNQVQKL
   121  IQELKEQKER AQWEKEHLEE RLLQTTRTLQ EMEAELQNLQ KSCLLQLARS SWVGRMLRSQ
   181  TGSVEVVTAE TLMDPSDLSE NIQAPTGEGF RLEDVDWNSV ARRYPNLFTN MEPSSKQKQP
   241  RPWPQLDTGS PESSGKHSER HHKTVEWGSL PCLNTSSSGG ADSDSSSCRP GLPSFVQVIG
   301  HPPRDHRASS EQALVQAGSY SRDSEDLQKT HSPRHGEPVL SPQPCTDPDH WSPELLQSPT
   361  GLKIVAVSCR EKFVRIFNPS QESTADLSGM VLKQLVRGFP ERLYRFPPGT LLAPRHHVTV
   421  WGEATRSAKK PLRASSSREP VPLLSIRGCA TLLLSPKGEV LSEHRIPRRE TPAPRVFADG
   481  TDLSIDRFPL PEAGPGADTR KPPRPPRPLR KGRVREPRVS RRRPGTRGLL PPVSSGKLFH
   541  AREGPARPEN PEIPAPQHLP AIPGDPTLPS PPAEAGLGLE DCRLQKEHRV RVCRKSVDRS
   601  CPLVALSVQN TAESRFGFRF LSCLPVTADT CRGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMNTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • testis: 27 nTPM
  • liver: 24 nTPM
  • kidney: 10 nTPM
  • thyroid gland: 8.4 nTPM
  • pancreas: 8.2 nTPM
  • skin: 6.7 nTPM

Single-cell type

  • late spermatids: 115 nCPM
  • early spermatids: 60 nCPM
  • tuft cells: 12 nCPM
  • late primary spermatocytes: 9.5 nCPM
  • proximal tubule cells: 8.8 nCPM
  • renal collecting duct principal cells: 6.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 5.8 nTPM
  • basal ganglia: 3.5 nTPM
  • cerebral cortex: 3.2 nTPM
  • pons: 2 nTPM
  • medulla oblongata: 1.8 nTPM
  • thalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMNTD2 as an antibody target. Whether an autoantibody or antibody against LMNTD2 could matter depends on whether native LMNTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMNTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMNTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LMNTD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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