Seroatlas · Human Serome Atlas

LMNTD1

Lamin tail domain-containing protein 1

Also known as: FLJ36004, IFLTD1, LMTD1_HUMAN, Pas1c1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9Z9
Gene: LMNTD1
Ensembl: ENSG00000152936
Chromosome: 12
Canonical length: 388 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to act upstream of or within cell population proliferation. Predicted to be located in intermediate filament and nucleus. Predicted to be active in cytoplasm and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q8N9Z9|LMNTD1
     1  MLEGSWINRR EDKLGVYSLV HFSPKMLGSV ATTLPLSSSN SSGMPLGYYL SSPQISRVTI
    61  STTGQLTSKA TVGSCSRVEN SLDASPFSVP KKQDESPMIG DGEDYFLSLF GDSKKLTAHS
   121  NYTQKTLKYF SMILEEVGQF TSSSLGDVEI AEVNVKGLFV KLINSSLDKE MAIGDHILQQ
   181  NVNGQTISLY RFLPNIVMQA NSTVTVWAAA SEAKHQPPSD FLWKEQDKFR ASPDCITILC
   241  KPNGQAIAWY TPIHWKQAWE KLDADVEFNR CSVVSPTFRK RVFQWTASTA TITKEKQDQP
   301  KKDISNYQVE QAQVLLKREK EIPPTVFPNR SPWCQNPYVS AHPYCPLIEP HNTSTAGGRL
   361  DRQPRTRSTR PNRASGSKKK KTSESQKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMNTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 16 nTPM
testis: 14 nTPM
colon: 3.4 nTPM
rectum: 3.2 nTPM
choroid plexus: 1.5 nTPM
duodenum: 1.3 nTPM

Single-cell type

ependymal cells: 1,132 nCPM
respiratory ciliated cells: 990 nCPM
endometrial ciliated cells: 405 nCPM
fallopian tube ciliated cells: 399 nCPM
retinal pigment epithelial cells: 337 nCPM
epididymal efferent duct ciliated cells: 319 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.4 nTPM
memory B-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
gdT-cell: 0.2 nTPM

Brain region

midbrain: 44 nTPM
medulla oblongata: 40 nTPM
white matter: 32 nTPM
spinal cord: 31 nTPM
hypothalamus: 26 nTPM
cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell population proliferation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Intermediate filament

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMNTD1 as an antibody target. Whether an autoantibody or antibody against LMNTD1 could matter depends on whether native LMNTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMNTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMNTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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