Seroatlas · Human Serome Atlas

LMLN

Leishmanolysin-like peptidase

Also known as: Gp63, LMLN_HUMAN, LMNL1, Msp

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96KR4
Gene
LMLN
Ensembl
ENSG00000185621
Chromosome
3
Canonical length
647 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>Q96KR4|LMLN
     1  MAAEWGGGVG YSGSGPGRSR WRWSGSVWVR SVLLLLGGLR ASATSTPVSL GSSPPCRHHV
    61  PSDTEVINKV HLKANHVVKR DVDEHLRIKT VYDKSVEELL PEKKNLVKNK LFPQAISYLE
   121  KTFQVRRPAG TILLSRQCAT NQYLRKENDP HRYCTGECAA HTKCGPVIVP EEHLQQCRVY
   181  RGGKWPHGAV GVPDQEGISD ADFVLYVGAL ATERCSHENI ISYAAYCQQE ANMDRPIAGY
   241  ANLCPNMIST QPQEFVGMLS TVKHEVIHAL GFSAGLFAFY HDKDGNPLTS RFADGLPPFN
   301  YSLGLYQWSD KVVRKVERLW DVRDNKIVRH TVYLLVTPRV VEEARKHFDC PVLEGMELEN
   361  QGGVGTELNH WEKRLLENEA MTGSHTQNRV LSRITLALME DTGRQMLSPY CDTLRSNPLQ
   421  LTCRQDQRAV AVCNLQKFPK PLPQEYQYFD ELSGIPAEDL PYYGGSVEIA DYCPFSQEFS
   481  WHLSGEYQRS SDCRILENQP EIFKNYGAEK YGPHSVCLIQ KSAFVMEKCE RKLSYPDWGS
   541  GCYQVSCSPQ GLKVWVQDTS YLCSRAGQVL PVSIQMNGWI HDGNLLCPSC WDFCELCPPE
   601  TDPPATNLTR ALPLDLCSCS SSLVVTLWLL LGNLFPLLAG FLLCIWH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 11 nTPM
  • retina: 9.1 nTPM
  • testis: 9 nTPM
  • pituitary gland: 6.2 nTPM
  • basal ganglia: 5.5 nTPM
  • fallopian tube: 4.2 nTPM

Single-cell type

  • ependymal cells: 131 nCPM
  • respiratory ciliated cells: 97 nCPM
  • choroid plexus epithelial cells: 76 nCPM
  • thyrotrophs: 69 nCPM
  • pituicytes/fscs: 69 nCPM
  • sertoli cells: 67 nCPM

Immune cell

  • naive CD8 T-cell: 0.5 nTPM
  • intermediate monocyte: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • pons: 12 nTPM
  • cerebral cortex: 12 nTPM
  • thalamus: 11 nTPM
  • medulla oblongata: 10 nTPM
  • midbrain: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
1.9

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMLN as an antibody target. Whether an autoantibody or antibody against LMLN could matter depends on whether native LMLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LMLN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...