Seroatlas · Human Serome Atlas

LMF2

Lipase maturation factor 2

Also known as: LMF2_HUMAN, TMEM112B, TMEM153

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BU23
Gene: LMF2
Ensembl: ENSG00000100258
Chromosome: 22
Canonical length: 707 aa
Protein class: Predicted membrane proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to be involved in protein maturation. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

707 residues, UniProt reviewed canonical sequence.

>Q9BU23|LMF2
     1  MAGSRLPRQL FLQGVAAVFM FAFASLYTQI PGLYGPEGIL PARRTLRPQG KGRWQQLWET
    61  PTLLWEAPRL GLDTAQGLEL LSLLGALVAL GALLLSPLRH PVIYLLLWAA YLSACQVGQV
   121  FLYFQWDSLL LETGFLAVLV APLRPASHRK EAPQGRQAGA LPHEDLPFWL VRWLLFRLMF
   181  ASGVVKLTSR CPAWWGLTAL TYHYETQCLP TPAAWFAHHL PVWLHKLSVV ATFLIEIAVP
   241  PLFFAPIRRL RLAAFYSQVL LQVLIIITGN YNFFNLMTLV LTTALLDDQH LAAEPGHGSR
   301  KKTATSWPKA LLATLSLLLE LAVYGLLAYG TVHYFGLEVD WQQRTIHSRT TFTFHQFSQW
   361  LKTLTLPTVW LGVASLVWEL LSALWRWTQV RGWLRKLSAV VQLSLVGTAT VALFLISLVP
   421  YSYVEPGTHG RLWTGAHRLF GAVEHLQLAN SYGLFRRMTG LGGRPEVVLE GSYDGHHWTE
   481  IEFMYKPGNL SRPPPVVVPH QPRLDWQMWF AALGPHTHSP WFTSLVLRLL QGKEPVIRLV
   541  QSQVARYPFH KQPPTYVRAQ RYKYWFSQPG EQGQWWRRQW VEEFFPSVSL GDPTLETLLR
   601  QFGLQEKSPP RTRSANSTLA QALHWTRSQL SPLEAPALLW GLLMAVGAVR FVQALLAPCS
   661  LRSSPLAPVS GEKRRPASQK DSGAASEQAT AAPNPCSSSS RTTRRKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 171 nTPM

Expression across tissuesHPA

Tissue

pancreas: 171 nTPM
pituitary gland: 61 nTPM
spleen: 58 nTPM
thyroid gland: 54 nTPM
liver: 54 nTPM
prostate: 49 nTPM

Single-cell type

extravillous trophoblasts: 138 nCPM
oocytes: 111 nCPM
cytotrophoblasts: 77 nCPM
pancreatic acinar cells: 72 nCPM
migrating cytotrophoblasts: 71 nCPM
enterocytes: 67 nCPM

Immune cell

plasmacytoid DC: 34 nTPM
gdT-cell: 26 nTPM
memory CD8 T-cell: 24 nTPM
intermediate monocyte: 23 nTPM
eosinophil: 22 nTPM
memory CD4 T-cell: 22 nTPM

Brain region

choroid plexus: 57 nTPM
medulla oblongata: 40 nTPM
hypothalamus: 36 nTPM
white matter: 35 nTPM
pons: 35 nTPM
cerebral cortex: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -2.52
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein maturation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMF2 as an antibody target. Whether an autoantibody or antibody against LMF2 could matter depends on whether native LMF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...