Seroatlas · Human Serome Atlas

LMF1

Lipase maturation factor 1

Also known as: C16orf26, FLJ12681, FLJ22302, JFP11, LMF1_HUMAN, TMEM112, TMEM112A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S06
Gene: LMF1
Ensembl: ENSG00000103227
Chromosome: 16
Canonical length: 567 aa
Protein class: Disease related genes, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

Involved in triglyceride metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Implicated in familial lipase maturation factor 1 deficiency. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q96S06|LMF1
     1  MRPDSPTMAA PAESLRRRKT GYSDPEPESP PAPGRGPAGS PAHLHTGTFW LTRIVLLKAL
    61  AFVYFVAFLV AFHQNKQLIG DRGLLPCRVF LKNFQQYFQD RTSWEVFSYM PTILWLMDWS
   121  DMNSNLDLLA LLGLGISSFV LITGCANMLL MAALWGLYMS LVNVGHVWYS FGWESQLLET
   181  GFLGIFLCPL WTLSRLPQHT PTSRIVLWGF RWLIFRIMLG AGLIKIRGDR CWRDLTCMDF
   241  HYETQPMPNP VAYYLHHSPW WFHRFETLSN HFIELLVPFF LFLGRRACII HGVLQILFQA
   301  VLIVSGNLSF LNWLTMVPSL ACFDDATLGF LFPSGPGSLK DRVLQMQRDI RGARPEPRFG
   361  SVVRRAANVS LGVLLAWLSV PVVLNLLSSR QVMNTHFNSL HIVNTYGAFG SITKERAEVI
   421  LQGTASSNAS APDAMWEDYE FKCKPGDPSR RPCLISPYHY RLDWLMWFAA FQTYEHNDWI
   481  IHLAGKLLAS DAEALSLLAH NPFAGRPPPR WVRGEHYRYK FSRPGGRHAA EGKWWVRKRI
   541  GAYFPPLSLE ELRPYFRDRG WPLPGPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

pancreas: 21 nTPM
spinal cord: 15 nTPM
salivary gland: 14 nTPM
choroid plexus: 13 nTPM
epididymis: 13 nTPM
thyroid gland: 12 nTPM

Single-cell type

retinal amacrine cells: 127 nCPM
distal convoluted tubule cells: 90 nCPM
proximal tubule cells: 86 nCPM
oligodendrocytes: 85 nCPM
renal collecting duct intercalated cells: 80 nCPM
prostatic glandular cells: 80 nCPM

Immune cell

myeloid DC: 8.3 nTPM
plasmacytoid DC: 7.6 nTPM
gdT-cell: 6.9 nTPM
NK-cell: 6.2 nTPM
intermediate monocyte: 5.9 nTPM
classical monocyte: 5.4 nTPM

Brain region

white matter: 45 nTPM
basal ganglia: 37 nTPM
medulla oblongata: 36 nTPM
cerebral cortex: 35 nTPM
amygdala: 32 nTPM
midbrain: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LMF1.

Disease | AllUniProt

Conditions LMF1 is implicated in, by any mechanism.

Combined lipase deficiency (CLD) MIM:246650

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 791 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Lipase deficiency, combined
Cardiovascular phenotype
Familial cancer of breast
LMF1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -1.79
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMF1 as an antibody target. Whether an autoantibody or antibody against LMF1 could matter depends on whether native LMF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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