Seroatlas · Human Serome Atlas

LMBRD2

G-protein coupled receptor-associated protein LMBRD2

Also known as: DKFZp434H2226, LMBD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68DH5
Gene: LMBRD2
Ensembl: ENSG00000164187
Chromosome: 5
Canonical length: 695 aa
Protein class: Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in adrenergic receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

695 residues, UniProt reviewed canonical sequence.

>Q68DH5|LMBRD2
     1  MSGAALGLEI VFVFFLALFL LHRYGDFKKQ HRLVIIGTLL AWYLCFLIVF ILPLDVSTTI
    61  YNRCKHAAAN SSPPENSNIT GLYATANPVP SQHPCFKPWS YIPDGIMPIF WRVVYWTSQF
   121  LTWILLPFMQ SYARSGGFSI TGKIKTALIE NAIYYGTYLL IFGAFLIYVA VNPHLHLEWN
   181  QLQTIGIAAA NTWGLFLLVL LLGYGLVEIP RSYWNGAKRG YLLMKTYFKA AKLMTEKADA
   241  EENLEDAMEE VRKVNESIKY NHPLRKCVDT ILKKCPTEYQ EKMGRNMDDY EDFDEKHSIY
   301  PSEKSLVKLH KQVIYSVQRH RRTQVQWQIL LEQAFYLEDV AKNETSATHQ FVHTFQSPEP
   361  ENRFIQYFYN PTFEWYWECL LRPWFYKILA VVLSIFSVIV VWSECTFFST TPVLSLFAVF
   421  IQLAEKTYNY IYIEIACFLS IFFLSICVYS TVFRIRVFNY YYLASHHQTD AYSLLFSGML
   481  FCRLTPPLCL NFLGLTHMDS SISHKNTQPT AYTSIMGSMK VLSFIADGFY IYYPMLVVIL
   541  CIATYFSLGT RCLNLLGFQQ FMGDDDMTSD LVNEGKELIR KEKRKRQRQE EGENRRREWK
   601  ERYGHNREDS TRNRNIHTDP KESNFSDVNT NRSAFKYTRA NNRTERDRIE LLQDAEPLDF
   661  NAETFTDDPL ESESGRYQPG GRYLSMSRSD IFNDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMBRD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 15 nTPM
parathyroid gland: 10 nTPM
liver: 9.7 nTPM
thyroid gland: 8.4 nTPM
tongue: 8 nTPM
stomach: 6.9 nTPM

Single-cell type

lactotrophs: 93 nCPM
adrenal medulla cells: 85 nCPM
corticotrophs: 73 nCPM
brain excitatory neurons: 69 nCPM
brain inhibitory neurons: 67 nCPM
thyrotrophs: 64 nCPM

Immune cell

basophil: 11 nTPM
T-reg: 1.6 nTPM
eosinophil: 1.4 nTPM
naive CD4 T-cell: 1.2 nTPM
naive CD8 T-cell: 1.2 nTPM
gdT-cell: 1 nTPM

Brain region

cerebral cortex: 34 nTPM
hippocampal formation: 32 nTPM
basal ganglia: 30 nTPM
white matter: 25 nTPM
thalamus: 25 nTPM
hypothalamus: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LMBRD2.

Disease | AllUniProt

Conditions LMBRD2 is implicated in, by any mechanism.

Developmental delay with variable neurologic and brain abnormalities (DENBA) MIM:619694

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 158 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental delay with variable neurologic and brain abnormalities
LMBRD2-related disorder
Neurodevelopmental disorder
brain structure abnormalities
Developmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 2.27
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

adrenergic receptor signaling pathway

Cellular components

Protein domainsUniProt · Pfam · InterPro

LMBR1-like membrane protein
LMBR1-like membrane protein
GPCR-associated LMBR1 domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMBRD2 as an antibody target. Whether an autoantibody or antibody against LMBRD2 could matter depends on whether native LMBRD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMBRD2 is annotated at the cell surface, where native LMBRD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LMBRD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...