Seroatlas · Human Serome Atlas

LMAN1L

Protein ERGIC-53-like

Also known as: ERGIC-53L, ERGL, LMA1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HAT1
Gene
LMAN1L
Ensembl
ENSG00000140506
Chromosome
15
Canonical length
526 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>Q9HAT1|LMAN1L
     1  MPAVSGPGPL FCLLLLLLDP HSPETGCPPL RRFEYKLSFK GPRLALPGAG IPFWSHHGDA
    61  ILGLEEVRLT PSMRNRSGAV WSRASVPFSA WEVEVQMRVT GLGRRGAQGM AVWYTRGRGH
   121  VGSVLGGLAS WDGIGIFFDS PAEDTQDSPA IRVLASDGHI PSEQPGDGAS QGLGSCHWDF
   181  RNRPHPFRAR ITYWGQRLRM SLNSGLTPSD PGEFCVDVGP LLLVPGGFFG VSAATGTLAD
   241  DHDVLSFLTF SLSEPSPEVP PQPFLEMQQL RLARQLEGLW ARLGLGTRED VTPKSDSEAQ
   301  GEGERLFDLE ETLGRHRRIL QALRGLSKQL AQAERQWKKQ LGPPGQARPD GGWALDASCQ
   361  IPSTPGRGGH LSMSLNKDSA KVGALLHGQW TLLQALQEMR DAAVRMAAEA QVSYLPVGIE
   421  HHFLELDHIL GLLQEELRGP AKAAAKAPRP PGQPPRASSC LQPGIFLFYL LIQTVGFFGY
   481  VHFRQELNKS LQECLSTGSL PLGPAPHTPR ALGILRRQPL PASMPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMAN1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 57 nTPM
  • heart muscle: 32 nTPM
  • spleen: 24 nTPM
  • cerebellum: 24 nTPM
  • salivary gland: 20 nTPM
  • stomach: 5.2 nTPM

Single-cell type

  • cardiomyocytes: 3.4 nCPM
  • prostatic glandular cells: 3.1 nCPM
  • cone photoreceptor cells: 2.1 nCPM
  • brain excitatory neurons: 1.4 nCPM
  • retinal bipolar cells: 1.1 nCPM
  • conjunctival goblet cells: 1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 29 nTPM
  • white matter: 8 nTPM
  • medulla oblongata: 6.1 nTPM
  • spinal cord: 5.4 nTPM
  • pons: 5.1 nTPM
  • basal ganglia: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
0.97
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMAN1L as an antibody target. Whether an autoantibody or antibody against LMAN1L could matter depends on whether native LMAN1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMAN1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMAN1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LMAN1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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