Seroatlas · Human Serome Atlas

LKAAEAR1

Protein LKAAEAR1

Also known as: C20orf201, LKAM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD35
Gene: LKAAEAR1
Ensembl: ENSG00000171695
Chromosome: 20
Canonical length: 194 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for LKAAEAR1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q8TD35|LKAAEAR1
     1  MPPPAKEGGR KGPRERSGKS APGTAQGEER AKGAPATEPP KPGWALTPQG LAAMLPAQRH
    61  RHLLFGDLLE DVGAAASTFP CGSVEPGYRM PDPRPWTQSL ELPAERQNRL LGVLKAAEAR
   121  GRVRALRLRY TRMRAEEIAL LIQRQKSARA AIRLELFLPP QLKPARIPDP LDRQERRRVE
   181  TILEENVDGT IFPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LKAAEAR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
amygdala: 5.7 nTPM
cerebral cortex: 5.6 nTPM
hypothalamus: 5.5 nTPM
basal ganglia: 5.1 nTPM
hippocampal formation: 3.6 nTPM

Single-cell type

late spermatids: 890 nCPM
early spermatids: 496 nCPM
late primary spermatocytes: 313 nCPM
fallopian tube ciliated cells: 76 nCPM
respiratory ciliated cells: 54 nCPM
endometrial ciliated cells: 45 nCPM

Immune cell

non-classical monocyte: 13 nTPM
intermediate monocyte: 8.2 nTPM
myeloid DC: 1 nTPM
eosinophil: 0.9 nTPM
total PBMC: 0.8 nTPM
naive CD4 T-cell: 0.7 nTPM

Brain region

thalamus: 7.4 nTPM
cerebral cortex: 7.3 nTPM
midbrain: 7.3 nTPM
amygdala: 7.2 nTPM
hypothalamus: 7.1 nTPM
basal ganglia: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.03
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein LKAAEAR1
Family of unknown function with LKAAEAR motif

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LKAAEAR1 as an antibody target. Whether an autoantibody or antibody against LKAAEAR1 could matter depends on whether native LKAAEAR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LKAAEAR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LKAAEAR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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