Seroatlas · Human Serome Atlas

LIX1L

LIX1-like protein

Also known as: LIX1L_HUMAN, MGC46719

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVB5
Gene: LIX1L
Ensembl: ENSG00000271601
Chromosome: 1
Canonical length: 337 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be involved in autophagosome maturation. Predicted to act upstream of or within actin cytoskeleton organization; gene expression; and mitral valve development. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q8IVB5|LIX1L
     1  METMRAQRLQ PGVGTSGRGT LRALRPGVTG AAAATATPPA GPPPAPPPPA PPPPPLLLSG
    61  APGLPLPPGA AGSPAVLREA VEAVVRSFAK HTQGYGRVNV VEALQEFWQM KQSRGADLKN
   121  GALVVYEMVP SNSPPYVCYV TLPGGSCFGS FQFCPTKAEA RRSAAKIALM NSVFNEHPSR
   181  RITDEFIEKS VSEALASFNG NREEADNPNT GIGAFRFMLE SNKGKSMLEF QELMTVFQLL
   241  HWNGSLKAMR ERQCSRQEVL AHYSHRALDD DIRHQMALDW VSREQSVPGA LSRELASTER
   301  ELDEARLAGK ELRFHKEKKD ILVLAAGQLG NMHSSNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIX1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 33 nTPM
blood vessel: 31 nTPM
ovary: 30 nTPM
tongue: 29 nTPM
endometrium: 27 nTPM
cervix: 26 nTPM

Single-cell type

thymic myoid cells: 93 nCPM
myonuclei: 70 nCPM
peritubular myoid cells: 64 nCPM
vascular smooth muscle cells: 63 nCPM
ovarian stromal cells: 60 nCPM
megakaryocytes: 56 nCPM

Immune cell

naive CD8 T-cell: 7.9 nTPM
MAIT T-cell: 7 nTPM
memory CD4 T-cell: 6.5 nTPM
naive CD4 T-cell: 6 nTPM
memory CD8 T-cell: 5.7 nTPM
gdT-cell: 5.6 nTPM

Brain region

thalamus: 29 nTPM
choroid plexus: 28 nTPM
medulla oblongata: 27 nTPM
midbrain: 27 nTPM
basal ganglia: 27 nTPM
amygdala: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 1.52
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

autophagosome maturation

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIX1L as an antibody target. Whether an autoantibody or antibody against LIX1L could matter depends on whether native LIX1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIX1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIX1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...