Seroatlas · Human Serome Atlas

LIX1

Protein limb expression 1 homolog

Also known as: C5orf11, Lft, LIX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N485
Gene: LIX1
Ensembl: ENSG00000145721
Chromosome: 5
Canonical length: 282 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Predicted to be involved in autophagosome maturation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q8N485|LIX1
     1  MDRTLESLRH IIAQVLPHRD PALVFKDLNV VSMLQEFWES KQQQKAAFPS EGVVVYESLP
    61  APGPPFVSYV TLPGGSCFGN FQCCLSRAEA RRDAAKVALI NSLFNELPSR RITKEFIMES
   121  VQEAVASTSG TLDDADDPST SVGAYHYMLE SNMGKTMLEF QELMTIFQLL HWNGSLKALR
   181  ETKCSRQEVI SYYSQYSLDE KMRSHMALDW IMKERDSPGI VSQELRMALR QLEEARKAGQ
   241  ELRFYKEKKE ILSLALTQIC SDPDTSSPSD DQLSLTALCG YH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

retina: 40 nTPM
cerebral cortex: 26 nTPM
basal ganglia: 25 nTPM
amygdala: 23 nTPM
midbrain: 21 nTPM
hypothalamus: 18 nTPM

Single-cell type

müller glia: 210 nCPM
pituitary stem cells: 60 nCPM
epididymal efferent duct absorptive cells: 53 nCPM
astrocytes: 51 nCPM
loop of henle epithelial cells: 37 nCPM
b-cells: 20 nCPM

Immune cell

naive B-cell: 2.2 nTPM
memory B-cell: 0.7 nTPM
basophil: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

midbrain: 64 nTPM
spinal cord: 64 nTPM
medulla oblongata: 62 nTPM
hypothalamus: 61 nTPM
white matter: 55 nTPM
thalamus: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

autophagosome maturation

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIX1 as an antibody target. Whether an autoantibody or antibody against LIX1 could matter depends on whether native LIX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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