Seroatlas · Human Serome Atlas

LITAFD

LITAF domain-containing protein

Also known as: LITAD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVX0
Gene
LITAFD
Ensembl
ENSG00000283516
Chromosome
16
Canonical length
72 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

72 residues, UniProt reviewed canonical sequence.

>A0A1B0GVX0|LITAFD
     1  MPVQAVCPYC GNRIITVTTF VPGALTWLLC TTLFLFGYVL GCCFLAFCIR SLMDVKHSCP
    61  VCQRELFYYH RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LITAFD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
6.8 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.8 nTPM
  • bone marrow: 0.3 nTPM
  • pituitary gland: 0.2 nTPM
  • epididymis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • late spermatids: 328 nCPM
  • early spermatids: 207 nCPM
  • late primary spermatocytes: 9.8 nCPM
  • epicardial cells: 2.3 nCPM
  • thymocytes: 1.7 nCPM
  • thymic myoid cells: 1.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 2.7 nTPM
  • cerebellum: 2.2 nTPM
  • hippocampal formation: 1.6 nTPM
  • amygdala: 1.5 nTPM
  • basal ganglia: 1.1 nTPM
  • hypothalamus: 1.1 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LITAFD as an antibody target. Whether an autoantibody or antibody against LITAFD could matter depends on whether native LITAFD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LITAFD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LITAFD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LITAFD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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