Seroatlas · Human Serome Atlas

LIPT2

Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial

Also known as: LIPT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NK58
Gene
LIPT2
Ensembl
ENSG00000175536
Chromosome
11
Canonical length
231 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a mitochondrial protein that catalyzes the transfer of octanoic acid to lipoate-dependent enzymes such as octanoyl-ACP. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>A6NK58|LIPT2
     1  MRQPAVRLVR LGRVPYAELL GLQDRWLRRL QAEPGIEAPS GTEAGALLLC EPAGPVYTAG
    61  LRGGLTPEET ARLRALGAEV RVTGRGGLAT FHGPGQLLCH PVLDLRRLGL RLRMHVASLE
   121  ACAVRLCELQ GLQDARARPP PYTGVWLDDR KICAIGVRCG RHITSHGLAL NCSTDLTWFE
   181  HIVPCGLVGT GVTSLSKELQ RHVTVEEVMP PFLVAFKEIY KCTLISEDSP N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIPT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • skeletal muscle: 7.5 nTPM
  • tongue: 6.6 nTPM
  • kidney: 4.3 nTPM
  • duodenum: 3.5 nTPM
  • small intestine: 3.4 nTPM

Single-cell type

  • late primary spermatocytes: 80 nCPM
  • early spermatids: 61 nCPM
  • cardiomyocytes: 51 nCPM
  • oocytes: 37 nCPM
  • late spermatids: 35 nCPM
  • early primary spermatocytes: 29 nCPM

Immune cell

  • naive CD4 T-cell: 13 nTPM
  • naive CD8 T-cell: 11 nTPM
  • memory B-cell: 11 nTPM
  • naive B-cell: 11 nTPM
  • NK-cell: 8.4 nTPM
  • MAIT T-cell: 7.7 nTPM

Brain region

  • white matter: 7.8 nTPM
  • hypothalamus: 7 nTPM
  • medulla oblongata: 6.2 nTPM
  • pons: 6 nTPM
  • midbrain: 5.1 nTPM
  • thalamus: 5.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LIPT2.

Disease | AllUniProt

Conditions LIPT2 is implicated in, by any mechanism.

  • Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities (NELABA) MIM:617668

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 146 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Encephalopathy, neonatal severe, with lactic acidosis and brain abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0.63
gnomAD missense Z
-0.12
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIPT2 as an antibody target. Whether an autoantibody or antibody against LIPT2 could matter depends on whether native LIPT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIPT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIPT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIPT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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