LIPN
Lipase member N
Also known as: bA186O14.3, LIPL4, LIPN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VXI9
- Gene
- LIPN
- Ensembl
- ENSG00000204020
- Chromosome
- 10
- Canonical length
- 398 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011]
Canonical amino-acid sequenceUniProt
398 residues, UniProt reviewed canonical sequence.
>Q5VXI9|LIPN
1 MMWLLLTTTC LICGTLNAGG FLDLENEVNP EVWMNTSEII IYNGYPSEEY EVTTEDGYIL
61 LVNRIPYGRT HARSTGPRPV VYMQHALFAD NAYWLENYAN GSLGFLLADA GYDVWMGNSR
121 GNTWSRRHKT LSETDEKFWA FSFDEMAKYD LPGVIDFIVN KTGQEKLYFI GHSLGTTIGF
181 VAFSTMPELA QRIKMNFALG PTISFKYPTG IFTRFFLLPN SIIKAVFGTK GFFLEDKKTK
241 IASTKICNNK ILWLICSEFM SLWAGSNKKN MNQSRMDVYM SHAPTGSSVH NILHIKQLYH
301 SDEFRAYDWG NDADNMKHYN QSHPPIYDLT AMKVPTAIWA GGHDVLVTPQ DVARILPQIK
361 SLHYFKLLPD WNHFDFVWGL DAPQRMYSEI IALMKAYSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LIPN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.22
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- skin: 25 nTPM
- bone marrow: 2.7 nTPM
- appendix: 2.6 nTPM
- spleen: 1.8 nTPM
- breast: 1.6 nTPM
- adipose tissue: 1.2 nTPM
Single-cell type
- neutrophils: 253 nCPM
- monocytes: 80 nCPM
- neutrophil progenitors: 22 nCPM
- cdc: 15 nCPM
- macrophages: 8.8 nCPM
- suprabasal keratinocytes: 5.3 nCPM
Immune cell
- eosinophil: 10 nTPM
- non-classical monocyte: 8.5 nTPM
- intermediate monocyte: 7.5 nTPM
- neutrophil: 5.4 nTPM
- classical monocyte: 2.9 nTPM
- basophil: 1.1 nTPM
Brain region
- pons: 0.6 nTPM
- medulla oblongata: 0.4 nTPM
- cerebral cortex: 0.2 nTPM
- choroid plexus: 0.2 nTPM
- midbrain: 0.2 nTPM
- spinal cord: 0.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about LIPN.
Disease | AllUniProt
Conditions LIPN is implicated in, by any mechanism.
- Ichthyosis, congenital, autosomal recessive 8 (ARCI8) MIM:613943
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.94
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.1
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LIPN as an antibody target. Whether an autoantibody or antibody against LIPN could matter depends on whether native LIPN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LIPN is annotated as secreted, so native LIPN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label LIPN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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