Seroatlas · Human Serome Atlas

LIPM

Lipase member M

Also known as: bA304I5.1, LIPL3, LIPM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VYY2
Gene: LIPM
Ensembl: ENSG00000173239
Chromosome: 10
Canonical length: 423 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Endoplasmic reticulum
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable lipoprotein lipase activity. Predicted to be involved in cornification. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q5VYY2|LIPM
     1  MLETLSRQWI VSHRMEMWLL ILVAYMFQRN VNSVHMPTKA VDPEAFMNIS EIIQHQGYPC
    61  EEYEVATEDG YILSVNRIPR GLVQPKKTGS RPVVLLQHGL VGGASNWISN LPNNSLGFIL
   121  ADAGFDVWMG NSRGNAWSRK HKTLSIDQDE FWAFSYDEMA RFDLPAVINF ILQKTGQEKI
   181  YYVGYSQGTT MGFIAFSTMP ELAQKIKMYF ALAPIATVKH AKSPGTKFLL LPDMMIKGLF
   241  GKKEFLYQTR FLRQLVIYLC GQVILDQICS NIMLLLGGFN TNNMNMSRAS VYAAHTLAGT
   301  SVQNILHWSQ AVNSGELRAF DWGSETKNLE KCNQPTPVRY RVRDMTVPTA MWTGGQDWLS
   361  NPEDVKMLLS EVTNLIYHKN IPEWAHVDFI WGLDAPHRMY NEIIHLMQQE ETNLSQGRCE
   421  AVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIPM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skin: 27 nTPM
breast: 1.8 nTPM
cervix: 0.3 nTPM
appendix: 0.1 nTPM
bone marrow: 0.1 nTPM
skeletal muscle: 0.1 nTPM

Single-cell type

oocytes: 4.6 nCPM
suprabasal keratinocytes: 3.1 nCPM
mesothelial cells: 1.4 nCPM
gastric chief cells: 1.1 nCPM
neutrophils: 0.5 nCPM
neutrophil progenitors: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIPM as an antibody target. Whether an autoantibody or antibody against LIPM could matter depends on whether native LIPM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIPM is annotated as secreted, so native LIPM circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LIPM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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