Seroatlas · Human Serome Atlas

LIPK

Lipase member K

Also known as: bA186O14.2, LIPK_HUMAN, LIPL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VXJ0
Gene: LIPK
Ensembl: ENSG00000204021
Chromosome: 10
Canonical length: 399 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable lipoprotein lipase activity. Predicted to be involved in cornification. Predicted to be located in extracellular region. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>Q5VXJ0|LIPK
     1  MWQLLAAACW MLLLGSMYGY DKKGNNANPE ANMNISQIIS YWGYPYEEYD VTTKDGYILG
    61  IYRIPHGRGC PGRTAPKPAV YLQHGLIASA SNWICNLPNN SLAFLLADSG YDVWLGNSRG
   121  NTWSRKHLKL SPKSPEYWAF SLDEMAKYDL PATINFIIEK TGQKRLYYVG HSQGTTIAFI
   181  AFSTNPELAK KIKIFFALAP VVTVKYTQSP MKKLTTLSRR VVKVLFGDKM FHPHTLFDQF
   241  IATKVCNRKL FRRICSNFLF TLSGFDPQNL NMSRLDVYLS HNPAGTSVQN MLHWAQAVNS
   301  GQLQAFDWGN SDQNMMHFHQ LTPPLYNITK MEVPTAIWNG GQDIVADPKD VENLLPQIAN
   361  LIYYKLIPHY NHVDFYLGED APQEIYQDLI ILMEEYLQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIPK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skin: 27 nTPM
breast: 2.1 nTPM
cervix: 1.6 nTPM
placenta: 1.2 nTPM
vagina: 1 nTPM
esophagus: 0.5 nTPM

Single-cell type

suprabasal keratinocytes: 20 nCPM
esophageal apical cells: 16 nCPM
ocular epithelial cells: 3.7 nCPM
esophageal suprabasal cells: 2.3 nCPM
breast secretory cells: 2.2 nCPM
differentiating spermatogonia: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.2 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
spinal cord: 0.1 nTPM
thalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIPK as an antibody target. Whether an autoantibody or antibody against LIPK could matter depends on whether native LIPK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIPK is annotated as secreted, so native LIPK circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LIPK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...