Seroatlas · Human Serome Atlas

LIPJ

Lipase member J

Also known as: bA425M17.2, LIPJ_HUMAN, LIPL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W064
Gene: LIPJ
Ensembl: ENSG00000204022
Chromosome: 10
Canonical length: 366 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>Q5W064|LIPJ
     1  MNISQIISYW GYPDEEYDIV TEDGYILGLY RIPYWRTDNN KNLAQRVVVY LQHGLLTSAS
    61  SWISNLPNNS LGFILADAGY DVWMGNSRGN TWSRKHLYLE TSSKEFWAFS FDEMAKYDLP
   121  ASIDFTVKQT RQEEIFYVGH SQGTTIGFIT FSTISKIAER IKIFFALAPV FSTKYLKSPL
   181  IRMTYKWKSI VMAFSGNKDF LPKTSFKKFI GSKLCPLQIF DKICLNILFM MFGYDPKNLN
   241  MSRLDVYFSH NPAGTSVQNM LHWSQLLNST HLKAYDWGSP DLNLVHYNQT TSPLYNMTNM
   301  NVATAIWNGK SDLLADPEDV NILHSEITNH IYYKTISYYN HIDSLFGLDV YDQVYHEIID
   361  IIQDNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIPJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

testis: 6.5 nTPM
epididymis: 0.8 nTPM
fallopian tube: 0.6 nTPM
cerebellum: 0.5 nTPM
liver: 0.5 nTPM
thyroid gland: 0.5 nTPM

Single-cell type

late primary spermatocytes: 85 nCPM
early spermatids: 41 nCPM
ependymal cells: 28 nCPM
tuft cells: 12 nCPM
late spermatids: 9 nCPM
thymic myoid cells: 8.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 2.7 nTPM
cerebellum: 2.3 nTPM
midbrain: 1.3 nTPM
spinal cord: 0.9 nTPM
choroid plexus: 0.8 nTPM
hippocampal formation: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Lipase, eukaryotic
Alpha/Beta hydrolase fold
Partial AB-hydrolase lipase domain
Partial alpha/beta-hydrolase lipase region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIPJ as an antibody target. Whether an autoantibody or antibody against LIPJ could matter depends on whether native LIPJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIPJ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIPJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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