Seroatlas · Human Serome Atlas

LIPF

Gastric triacylglycerol lipase

Also known as: HGL, HLAL, LIPF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P07098
Gene: LIPF
Ensembl: ENSG00000182333
Chromosome: 10
Canonical length: 398 aa
Protein class: Enzymes, FDA approved drug targets, Metabolic proteins, Predicted secreted proteins
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>P07098|LIPF
     1  MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE VVTEDGYILE
    61  VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN SLAFILADAG YDVWLGNSRG
   121  NTWARRNLYY SPDSVEFWAF SFDEMAKYDL PATIDFIVKK TGQKQLHYVG HSQGTTIGFI
   181  AFSTNPSLAK RIKTFYALAP VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF
   241  LATEVCSREM LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS
   301  GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD VGLLLPKLPN
   361  LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIPF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 35,390 nTPM

Expression across tissuesHPA

Tissue

stomach: 35,390 nTPM
duodenum: 247 nTPM
esophagus: 99 nTPM
kidney: 11 nTPM
cerebral cortex: 11 nTPM
colon: 8 nTPM

Single-cell type

gastric chief cells: 139,374 nCPM
parietal cells: 42,347 nCPM
mucous neck cells: 29,153 nCPM
foveolar cells: 1,825 nCPM
neuroendocrine cells: 1,460 nCPM
submucosal glandular cells: 111 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.6 nTPM
midbrain: 0.3 nTPM
cerebellum: 0.2 nTPM
amygdala: 0.1 nTPM
choroid plexus: 0.1 nTPM
hippocampal formation: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipid binding
triacylglycerol lipase activity
malate dehydrogenase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIPF as an antibody target. Whether an autoantibody or antibody against LIPF could matter depends on whether native LIPF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIPF is annotated as secreted, so native LIPF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LIPF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...