LINS1

Protein identityUniProt · HPA

UniProt accession

Q8NG48

Gene

LINS1

Ensembl

ENSG00000140471

Chromosome

15

Canonical length

757 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered with the gene encoding ankyrin repeat and SOCS box-containing protein 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]

Canonical amino-acid sequenceUniProt

757 residues, UniProt reviewed canonical sequence.

>Q8NG48|LINS1
     1  MKVFCEVLEE LYKKVLLGAT LENDSHDYIF YLNPAVSDQD CSTATSLEWA NTCGIQGRHQ
    61  PISVGVAPIA VAPVCLKTNS QMSGSREVML LQLTVIKVMT TRILSVKTEF HAKEQYRDVI
   121  KILLESAKVD SKLICMFQNS DKLLSHMAAQ CLALLLYFQL REKITLSNSW IAFCQKNLSE
   181  YSESNKAIYC LWTLTAIIKE IFKDSCSQKT EILKQFLTHF DTIFEVFYNS LFSQHFENCR
   241  DTSKIVNILM CFLDLLELLI ASRIHLKLHF TCQRILFLKP SCMLEVITWP IQAFVKRKVI
   301  IFLKKCLLCK VGEDLCRGSV PALMPPDHHV AVDMLALANA VLQAVNSGLL KTLSVYEKHS
   361  FFGGDEVQPE CELITSPDHV ILRAASLVIM KSLEIKFQNY SSASEVKVDL QRFMSELLTF
   421  LKPHLQPSLQ LHNPCKWLSR VFIEQDDDML EAAKASLGIY LTLTRGCEAT ESLTQGKEMW
   481  DHHTHENGYN PHCIFLFFLK NIGFDSTVLL DFLISSETCF LEYFVRYLKL LQKDWDNFFT
   541  ICNNFDATES KYDISICGCV PSLVQDQSSN QTIPHRLTAP HSHRDVCARH SWASDAPSEP
   601  LKAVMSKGAH TMCASSLSSP RASQSLVDYD SSDDSDVEST EQCLANSKQT SLHQQATKEI
   661  QDAAGTSRDK KEFSLEPPSR PLVLKEFDTA FSFDCEVAPN DVVSEVGIFY RIVKCFQELQ
   721  DAICRLQKKN LFPYNPTALL KLLKYIEVIS NKTMNTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

11 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LINS1.

Disease | AllUniProt

Conditions LINS1 is implicated in, by any mechanism.

• Intellectual developmental disorder, autosomal recessive 27 (MRT27) MIM:614340

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 210 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual disability, autosomal recessive 27
• Inborn genetic diseases
• Intellectual disability
• Autism

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.96

gnomAD pLI

0

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cognition

Protein domainsUniProt · Pfam · InterPro

• Protein Lines
• Protein Lines, C-terminal
• Protein Lines, N-terminal
• Lines N-terminus
• Lines C-terminus

KeywordsUniProt

• Intellectual disability
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of LINS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRPF19