Seroatlas · Human Serome Atlas

LINC03040

Uncharacterized protein LINC03040

Also known as: CF223_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N319
Gene: LINC03040
Canonical length: 242 aa

OverviewNCBI Gene

No narrative summary is available for LINC03040 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q8N319|LINC03040
     1  MMPLAEAGAL AQGGGPSATE WACILRRKTP RHKQPTLLMV RASRRSGKTS AVLKAGRQSV
    61  SGRKNSTSKD LVTLGASSLR EERGHPLHPR HRKAVHLRTR GRTRGWVQTL ARMSRRTRGP
   121  VERAAAAAAA AAGGDAGHAP FPPPPAADGA RAPRSPGQVT PRGLRLRLPR RESLLRGLCR
   181  PLRPLLGFRE SDSAKPASLR LLQHTPSARR NYRIAGARLM RSNYPPPLSS AALRGAGPTR
   241  RN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINC03040 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF5550
Family of unknown function (DUF5550)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINC03040 as an antibody target. Whether an autoantibody or antibody against LINC03040 could matter depends on whether native LINC03040 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINC03040 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LINC03040 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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