Seroatlas · Human Serome Atlas

LINC00696

Putative uncharacterized protein encoded by LINC00696

Also known as: CC074_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRV3
Gene: LINC00696
Canonical length: 163 aa

OverviewNCBI Gene

No narrative summary is available for LINC00696 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q6ZRV3|LINC00696
     1  MQSVDSMLGT VGGCGGGEAA STFSKDPSGC CVGNDCRDGG RGLERRHGRW SRGEGGESGL
    61  CSGGQMASEI EYWDGLAISV MEVEKAFGST NVLWKTEPFS LWACTAACPP SLSPTLLALG
   121  LPRDGKELAE QGSLWTVLEP GGDWSHSQSQ LGTPGRGKGA LGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINC00696 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINC00696 as an antibody target. Whether an autoantibody or antibody against LINC00696 could matter depends on whether native LINC00696 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINC00696 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LINC00696 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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