Seroatlas · Human Serome Atlas

LINC00473

Putative transcriptional regulator encoded by LINC00473

Also known as: CF176_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8K010
Gene
LINC00473
Canonical length
186 aa

OverviewNCBI Gene

No narrative summary is available for LINC00473 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>A8K010|LINC00473
     1  MELSAAAGRR RQAPWREFTG RHRTERSQER GSTPRKERSM GSRQPRKRER EPRDCTPTCT
    61  NAASVSRSGA RRAPGCAGRC ITMKNCARAW RELSERACCF QAVPPSNMKQ SWLIFLDTTL
   121  CSAWLLASSC PRLYAPLISF HCMCFNTVLL FPRLFGPTLS AKIQFNTDLS LRAIAWKCTK
   181  DTTTYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINC00473 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINC00473 as an antibody target. Whether an autoantibody or antibody against LINC00473 could matter depends on whether native LINC00473 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINC00473 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LINC00473 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LINC00473. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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