Seroatlas · Human Serome Atlas

LINC00469

Putative uncharacterized protein encoded by LINC00469

Also known as: CQ054_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N7U9
Gene
LINC00469
Canonical length
141 aa

OverviewNCBI Gene

No narrative summary is available for LINC00469 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>Q8N7U9|LINC00469
     1  MTSSAPTLPD VTIRNVSRHI QMSLMGKGEP PWLCRLQLEP LLQAMEEQQL GNLEARWEVE
    61  KHGNEVSGST SREVWEDADF ICPVLKQCTN PKLNENKNIH QAKECEKSPF LSLSPHQQWK
   121  PGLPRRNDAL PTSLCLCCSE N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINC00469 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINC00469 as an antibody target. Whether an autoantibody or antibody against LINC00469 could matter depends on whether native LINC00469 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINC00469 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LINC00469 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LINC00469. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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