Seroatlas · Human Serome Atlas

LINC00336

Putative uncharacterized protein encoded by LINC00336

Also known as: NC336_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUF6
Gene: LINC00336
Canonical length: 198 aa

OverviewNCBI Gene

No narrative summary is available for LINC00336 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q6ZUF6|LINC00336
     1  MRAPAQVRTL RWSLGWPGSR GRDVFAALRC AQALRCQPLG SALPPQAPTR DLGRPQAFDS
    61  SRTPGPRPPR STLRMMETKS PTSPSYGARG KVPPGAGPGS PLSRGAGQGA PLSETRFHHV
   121  AQAFLKLLSS SNPPTSASES ARIIGVSHCT QPQVASLSDR HCSKVNHTVL SPRKGVPLQL
   181  TAAHSSSQEV LATVPFHG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINC00336 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINC00336 as an antibody target. Whether an autoantibody or antibody against LINC00336 could matter depends on whether native LINC00336 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINC00336 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LINC00336 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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