Seroatlas · Human Serome Atlas

LINC00305

Putative uncharacterized protein encoded by LINC00305

Also known as: CR020_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4B0
Gene: LINC00305
Canonical length: 112 aa

OverviewNCBI Gene

No narrative summary is available for LINC00305 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q7Z4B0|LINC00305
     1  MINLHRLCII HVVATLLSTL LSLISVAISA TCKDEKGKQE METGQQPSGL SATLTKVKCA
    61  KRQKTVVRVR FYMLSMKNKA CRKNLSKGYN QRPEGSKEES HMVVKEKRKG DH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINC00305 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINC00305 as an antibody target. Whether an autoantibody or antibody against LINC00305 could matter depends on whether native LINC00305 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINC00305 is annotated as secreted, so native LINC00305 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LINC00305 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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