Seroatlas · Human Serome Atlas

LINC00114

Putative uncharacterized protein encoded by LINC00114

Also known as: CU024_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6XXX2
Gene: LINC00114
Canonical length: 140 aa

OverviewNCBI Gene

No narrative summary is available for LINC00114 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q6XXX2|LINC00114
     1  MQTTWQPGCS YPTSWLSSQE SFSKMRTGWR GAIPLRWRNR ARNREKPHSP RAVSSPATHS
    61  LPPSNPCRLT PTLSSARPRE GSCPSKCSCP GGNWSNTALS AELMWAEGRF SGGCLPVYMR
   121  QNINPGCQEQ WEGEERSRWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LINC00114 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LINC00114 as an antibody target. Whether an autoantibody or antibody against LINC00114 could matter depends on whether native LINC00114 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LINC00114 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LINC00114 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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