Seroatlas · Human Serome Atlas

LIN52

Protein lin-52 homolog

Also known as: LIN52_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q52LA3
Gene
LIN52
Canonical length
116 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for LIN52 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q52LA3|LIN52
     1  MGWKMASPTD GTDLEASLLS FEKLDRASPD LWPEQLPGVA EFAASFKSPI TSSPPKWMAE
    61  IERDDIDMLK ELGSLTTANL MEKVRGLQNL AYQLGLDESR EMTRGKFLNI LEKPKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIN52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 16 nTPM
  • cerebellum: 11 nTPM
  • hypothalamus: 9.6 nTPM
  • retina: 9.3 nTPM
  • cerebral cortex: 8.7 nTPM
  • thymus: 8.2 nTPM

Single-cell type

  • proximal tubule cells: 333 nCPM
  • myonuclei: 213 nCPM
  • plasma cells: 116 nCPM
  • choroid plexus epithelial cells: 110 nCPM
  • cone photoreceptor cells: 108 nCPM
  • erythrocyte progenitors: 104 nCPM

Immune cell

  • eosinophil: 17 nTPM
  • MAIT T-cell: 14 nTPM
  • T-reg: 13 nTPM
  • naive CD4 T-cell: 11 nTPM
  • naive CD8 T-cell: 11 nTPM
  • NK-cell: 9.6 nTPM

Brain region

  • hypothalamus: 13 nTPM
  • pons: 12 nTPM
  • cerebral cortex: 11 nTPM
  • midbrain: 11 nTPM
  • cerebellum: 11 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.92
gnomAD missense Z
1.05
DepMap mean gene effect
-0.55
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protein LIN52
  • Retinal tissue protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIN52 as an antibody target. Whether an autoantibody or antibody against LIN52 could matter depends on whether native LIN52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIN52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIN52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIN52. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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