Seroatlas · Human Serome Atlas

LIMS4

LIM and senescent cell antigen-like-containing domain protein 4

Also known as: LIMS3L, LIMS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CW20
Gene
LIMS4
Ensembl
ENSG00000256671
Chromosome
2
Canonical length
117 aa
Protein class
Predicted intracellular proteins
Subcellular location
Focal adhesion sites,Cytosol

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm; focal adhesion; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P0CW20|LIMS4
     1  MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV YKEFCDFYAK
    61  FNMANALASA TCERCKGGFA PAETIVNSNG ELYHEQCFVC AQCFQQFPEG LFYEERT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIMS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 8 nTPM
  • skeletal muscle: 4.1 nTPM
  • heart muscle: 2.2 nTPM
  • adrenal gland: 2 nTPM
  • kidney: 1.9 nTPM
  • endometrium: 1.7 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 4 nTPM
  • neutrophil: 0.6 nTPM
  • T-reg: 0.4 nTPM
  • eosinophil: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • classical monocyte: 0.2 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • choroid plexus: 1.6 nTPM
  • white matter: 1.6 nTPM
  • cerebellum: 1.5 nTPM
  • medulla oblongata: 1.4 nTPM
  • pons: 1.4 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIMS4 as an antibody target. Whether an autoantibody or antibody against LIMS4 could matter depends on whether native LIMS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIMS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIMS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIMS4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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