Seroatlas · Human Serome Atlas

LIMS3

LIM and senescent cell antigen-like-containing domain protein 3

Also known as: LIMS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CW19
Gene
LIMS3
Ensembl
ENSG00000256977
Chromosome
2
Canonical length
117 aa
Protein class
Predicted intracellular proteins
Subcellular location
Focal adhesion sites,Cytosol

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to be located in cytoplasm; focal adhesion; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P0CW19|LIMS3
     1  MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV YKEFCDFYAK
    61  FNMANALASA TCERCKGGFA PAETIVNSNG ELYHEQCFVC AQCFQQFPEG LFYEERT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIMS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
7.1 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 7.1 nTPM
  • fallopian tube: 3.2 nTPM
  • endometrium: 3 nTPM
  • kidney: 2.4 nTPM
  • choroid plexus: 2 nTPM
  • adrenal gland: 1.8 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • eosinophil: 1.4 nTPM
  • basophil: 0.3 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1 nTPM
  • medulla oblongata: 0.9 nTPM
  • pons: 0.9 nTPM
  • cerebral cortex: 0.8 nTPM
  • midbrain: 0.8 nTPM
  • thalamus: 0.8 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIMS3 as an antibody target. Whether an autoantibody or antibody against LIMS3 could matter depends on whether native LIMS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIMS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIMS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIMS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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