Seroatlas · Human Serome Atlas

LILRB5

Leukocyte immunoglobulin-like receptor subfamily B member 5

Also known as: CD85c, LIR-8, LIR8, LIRB5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75023
Gene: LILRB5
Ensembl: ENSG00000105609
Chromosome: 19
Canonical length: 590 aa
Protein class: CD markers, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>O75023|LILRB5
     1  MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL
    61  DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGF
   121  YAEPTLLALP SPVVASGGNV TLQCDTLDGL LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF
   181  PVGPVTPSCR WRFRCYYYYR KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL
   241  TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN
   301  LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI DTFFLTKEGA
   361  AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR SYPYLLSSPS YPQELVVSGP
   421  SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR
   481  HRHQSKHRTS AHFYRPAGAA GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD
   541  APAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LILRB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

spleen: 45 nTPM
adipose tissue: 16 nTPM
adrenal gland: 9.1 nTPM
liver: 6.6 nTPM
breast: 6.5 nTPM
small intestine: 6.4 nTPM

Single-cell type

macrophages: 14 nCPM
kupffer cells: 4.1 nCPM
hofbauer cells: 1.5 nCPM
adipocytes: 0.9 nCPM
lacrimal acinar cells: 0.9 nCPM
microglia: 0.9 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.3 nTPM
NK-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

choroid plexus: 4.7 nTPM
thalamus: 4.1 nTPM
cerebral cortex: 3.9 nTPM
white matter: 3.9 nTPM
basal ganglia: 3 nTPM
medulla oblongata: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -1
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LILRB5 as an antibody target. Whether an autoantibody or antibody against LILRB5 could matter depends on whether native LILRB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LILRB5 is annotated at the cell surface, where native LILRB5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LILRB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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