LILRB4

Protein identityUniProt · HPA

UniProt accession

Q8NHJ6

Gene

LILRB4

Ensembl

ENSG00000186818

Chromosome

19

Canonical length

448 aa

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

448 residues, UniProt reviewed canonical sequence.

>Q8NHJ6|LILRB4
     1  MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL
    61  DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA
   121  YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF
   181  PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEDPRPSPTR SVSTAAGPED
   241  QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR
   301  PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP HDEDPQAVTY
   361  AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE AAASEAPQDV TYAQLHSFTL
   421  RQKATEPPPS QEGASPAEPS VYATLAIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LILRB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

18 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0

gnomAD missense Z

-1.43

DepMap mean gene effect

0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• cytokine-mediated signaling pathway
• Fc receptor mediated inhibitory signaling pathway
• immune response-regulating signaling pathway
• interleukin-10-mediated signaling pathway
• negative regulation of activated T cell proliferation
• negative regulation of canonical NF-kappaB signal transduction
• negative regulation of chemokine production
• negative regulation of cytokine production involved in inflammatory response
• negative regulation of interleukin-1 beta production
• negative regulation of interleukin-10 production
• negative regulation of interleukin-2 production
• negative regulation of interleukin-5 production
• negative regulation of interleukin-6 production
• negative regulation of intracellular signal transduction
• negative regulation of IP-10 production
• negative regulation of MAPK cascade
• negative regulation of miRNA transcription
• negative regulation of monocyte activation
• negative regulation of osteoclast differentiation
• negative regulation of protein localization to nucleus
• negative regulation of T cell costimulation
• negative regulation of T cell cytokine production
• negative regulation of T cell proliferation
• negative regulation of T cell receptor signaling pathway
• negative regulation of tumor necrosis factor production
• negative regulation of type II interferon production
• positive regulation of CD8-positive, alpha-beta T cell differentiation
• positive regulation of regulatory T cell differentiation
• positive regulation of T cell anergy
• receptor internalization
• tolerance induction
• negative regulation of cytotoxic T cell differentiation

Molecular functions

• apolipoprotein binding
• fibronectin binding
• inhibitory MHC class I receptor activity
• protein phosphatase binding
• protein tyrosine kinase inhibitor activity
• signaling receptor inhibitor activity
• transmembrane receptor protein tyrosine kinase inhibitor activity

Cellular components

• cell surface
• cytoplasmic side of plasma membrane
• extracellular exosome
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin-like domain
• Immunoglobulin-like beta-sandwich domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Immunoglobulin-like Receptors in Immune Regulation
• Immunoglobulin domain
• Immunoglobulin domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Disulfide bond
• Immunity
• Immunoglobulin domain
• Membrane
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LILRB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PTPN6