Seroatlas · Human Serome Atlas

LILRA5

Leukocyte immunoglobulin-like receptor subfamily A member 5

Also known as: CD85, CD85f, ILT11, LILRB7, LIR9, LIRA5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NI73
Gene
LILRA5
Ensembl
ENSG00000187116
Chromosome
19
Canonical length
299 aa
Protein class
CD markers, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>A6NI73|LILRA5
     1  MAPWSHPSAQ LQPVGGDAVS PALMVLLCLG LSLGPRTHVQ AGNLSKATLW AEPGSVISRG
    61  NSVTIRCQGT LEAQEYRLVK EGSPEPWDTQ NPLEPKNKAR FSIPSMTEHH AGRYRCYYYS
   121  PAGWSEPSDP LELVVTGFYN KPTLSALPSP VVTSGENVTL QCGSRLRFDR FILTEEGDHK
   181  LSWTLDSQLT PSGQFQALFP VGPVTPSHRW MLRCYGSRRH ILQVWSEPSD LLEIPVSGAA
   241  DNLSPSQNKS DSGTASHLQD YAVENLIRMG MAGLILVVLG ILIFQDWHSQ RSPQAAAGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LILRA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 73 nTPM
  • bone marrow: 41 nTPM
  • appendix: 34 nTPM
  • lung: 21 nTPM
  • urinary bladder: 15 nTPM
  • adipose tissue: 7.5 nTPM

Single-cell type

  • neutrophils: 23 nCPM
  • monocytes: 12 nCPM
  • neutrophil progenitors: 3.7 nCPM
  • platelets: 2.8 nCPM
  • macrophages: 1.5 nCPM
  • monocyte progenitors: 1.4 nCPM

Immune cell

  • non-classical monocyte: 313 nTPM
  • intermediate monocyte: 253 nTPM
  • neutrophil: 138 nTPM
  • classical monocyte: 129 nTPM
  • total PBMC: 65 nTPM
  • myeloid DC: 39 nTPM

Brain region

  • cerebral cortex: 1.8 nTPM
  • choroid plexus: 1.1 nTPM
  • medulla oblongata: 1.1 nTPM
  • pons: 1 nTPM
  • thalamus: 0.8 nTPM
  • white matter: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
-0.15
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LILRA5 as an antibody target. Whether an autoantibody or antibody against LILRA5 could matter depends on whether native LILRA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LILRA5 is annotated at the cell surface, where native LILRA5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LILRA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LILRA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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